|| common in complete genomics
( -421C/A ) is a SNP in close proximity to GRIN2B
(Glutamate [NMDA] receptor subunit epsilon-2).
[PMID 18983893] significant differences in genotype between the North Chinese sporadic Alzheimer's patients (of which there were 362) and controls (of which there were 334). 34.69-39.79% decreased transcriptional activity (per luciferase reporter assay in SH-SY5Y and HeLa cell lines) noted for the C allele versus the A allele
[PMID 25693086] The relationship of TP53 and GRIN2B gene polymorphisms with risk of occurrence and progression of primary open-angle glaucoma in a Polish population