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From SNPedia

Geno Mag Summary
(C;C) 2.1 ~1.2x increased risk for cancer
(C;T) 2 ~1.2x increased risk for cancer
(T;T) 2.1 decreased cancer risk
ReferenceGRCh38 38.1/141
GeneLOC107985393, MIR499A, MIR499B, MYH7B
is asnp
is mentioned by
dbSNP (classic)rs3746444
1000 genomesrs3746444
GWAS Ctlgrs3746444
Max Magnitude2.1

[PMID 18634034] microRNA 1,009 breast cancer cases and 1,093 controls in a population of Chinese women

[PMID 19293314] A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese.

[PMID 19514064] Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population

[PMID 19847796] Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases

[PMID 20488170] Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy

[PMID 20549817OA-icon.png] Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck

[PMID 20842445] Genetic variation in microRNA genes and prostate cancer risk in North Indian population

[PMID 20848167] Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis

[PMID 21073609] Association Between Common Genetic Variants in Pre-microRNAs and Gastric Cancer Risk in Japanese Population

[PMID 21524676] Genetic study of two single nucleotide polymorphisms within corresponding microRNAs and susceptibility to tuberculosis in a Chinese Tibetan and Han population

[PMID 21861697OA-icon.png] Association Between Two Genetic Variants in miRNA and Primary Liver Cancer Risk in the Chinese Population

[PMID 21565178] Association between SNPs in pre-miRNA and risk of chronic obstructive pulmonary disease

[PMID 22451023] IRAK1 rs3027898 C/A polymorphism is associated with risk of rheumatoid arthritis

[PMID 18521189OA-icon.png] Genetic variants of miRNA sequences and non-small cell lung cancer survival.

[PMID 19458495OA-icon.png] Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.

[PMID 19617315OA-icon.png] SNPs in human miRNA genes affect biogenesis and function.

[PMID 19881472] Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis.

[PMID 20428464OA-icon.png] MicroRNA polymorphisms: a giant leap towards personalized medicine.

[PMID 20520619] Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population.

[PMID 20845080] Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus.

[PMID 21181275] Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population.

[PMID 21319225] Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma.

[PMID 21345130] Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India.

[PMID 21663520] Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.

[PMID 21713406] Association between two single nucleotide polymorphisms at corresponding microRNA and schizophrenia in a Chinese population.

[PMID 21902575] Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.

[PMID 22019503] Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population.

[PMID 22159951] Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease.

[PMID 22311030] Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population.

[PMID 23138379] Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis

[PMID 23236400OA-icon.png] Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies

[PMID 23271127] The association between common genetic variant of microRNA-499 and cancer susceptibility: a meta-analysis

[PMID 23437296OA-icon.png] The Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population

[PMID 23470291] Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC

[PMID 23219900OA-icon.png] Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx

[PMID 23613771OA-icon.png] Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review

[PMID 23679271] Positive Association Between miR-499A>G and Hepatocellular Carcinoma Risk in a Chinese Population

[PMID 23728616] Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population

[PMID 23725137] Association of mir-499 and mir-149 Polymorphisms with Cancer Risk in the Chinese Population: Evidence from Published Studies

[PMID 23888320] A functional polymorphism in the miR-146a gene is associated with the risk of childhood acute lymphoblastic leukemia: a preliminary report

[PMID 24085457] An A/G polymorphism rs3746444 in miR-499 is associated with increased cancer risk: a meta-analysis

[PMID 24102488] Meta-analysis of pre-miRNA polymorphisms association with susceptibility to autoimmune diseases

[PMID 24107911] Association of the hsa-mir-499 (rs3746444) Polymorphisms with Gastric Cancer Risk in the Chinese Population

[PMID 24136745] Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population

[PMID 23791656] Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis

[PMID 24194751OA-icon.png] Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation

[PMID 24254303] Two functional polymorphisms in microRNAs and lung cancer risk: a meta-analysis

[PMID 24258110] Quantitative assessment of the association between microRNA-499 rs3746444 A/G polymorphism and cancer risk

[PMID 24301908] miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population

[PMID 24327058] MicroRNA-499 rs3746444 Polymorphism and Autoimmune Diseases Risk: A Meta-Analysis

[PMID 24413317OA-icon.png] MicroRNA sequence polymorphisms and the risk of different types of cancer

[PMID 24447667] A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression

[PMID 24568449] Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility

[PMID 24618566] Non-coding RNAs-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility

[PMID 22659075] Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population.

[PMID 22903035] The association between hsa-miR-499 T>C polymorphism and cancer risk: a meta-analysis.

[PMID 22922391] Hsa-miR-499 polymorphism (rs3746444) and cancer risk: a meta-analysis of 17 case-control studies.

[PMID 22970328OA-icon.png] Association of microRNA-499 rs3746444 polymorphism with cancer risk: evidence from 7188 cases and 8548 controls.

[PMID 23001871] Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population.

[PMID 23053947] miR-499 rs3746444 polymorphism is associated with cancer development among Asians and related to breast cancer susceptibility.

[PMID 23292097] Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis.

[PMID 23593385OA-icon.png] Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.

[PMID 23731641] Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients.

[PMID 24854593OA-icon.png] Identification of miR-423 and miR-499 Polymorphisms on Affecting the Risk of Hepatocellular Carcinoma in a Large-Scale Population

[PMID 24039706OA-icon.png] The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility

[PMID 24922658] Genetic Polymorphism of miR-196a as a Prognostic Biomarker for Early Breast Cancer

[PMID 24978643] Genetic variants of MicroRNA-related genes in susceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians

[PMID 25074528] rs3746444 Polymorphism and Susceptibility to Hepatocellular Carcinoma: Evidence from Published Studies

[PMID 25218914] Comprehensive Review of Genetic Association Studies and Meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility

[PMID 24681820] Genetic variations in microRNAs and the risk and survival of renal cell cancer

[PMID 25374621OA-icon.png] Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population

[PMID 25795117] Comprehensive assessment of the association between miRNA polymorphisms and gastric cancer risk

[PMID 25861865] Polymorphism in mature microRNA-608 sequence is associated with an increased risk of nasopharyngeal carcinoma

[PMID 25901206OA-icon.png] Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease

[PMID 25176041OA-icon.png] High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients

[PMID 26053525] Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease

[PMID 26112096] Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population

[PMID 26305248OA-icon.png] Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity

[PMID 26458899OA-icon.png] Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer

[PMID 26518769] Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population

[PMID 26597478] Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population

[PMID 26608782OA-icon.png] Association Between Single-Nucleotide Polymorphism (SNP) in miR-146a, miR-196a2, and miR-499 and Risk of Ischemic Stroke: A Meta-Analysis.

[PMID 26886638OA-icon.png] The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study.

[PMID 27509977] Combined Genotype Analyses of Precursor miRNA196a2 and 499a Variants with Hepatic and Renal Cancer Susceptibility a Preliminary Study.

[PMID 27813602] Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population.

[PMID 27888002] Polymorphisms in MIR499A and MIR125A gene are associated with autoimmune thyroid diseases.

[PMID 28301487OA-icon.png] Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs.

[PMID 28886711OA-icon.png] Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma.

[PMID 28922434] Association of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population.

[PMID 29108839] Association between a MIR499A polymorphism and diabetic neuropathy in type 2 diabetes.

[PMID 30084801] Association of a MiR-499 SNP and risk of congenital heart disease in a Chinese population.

[PMID 30229913] Association of the genetic polymorphisms in immunoinflammatory microRNAs with risk of ischemic stroke and subtypes in an Iranian population.

[PMID 30864695] Single nucleotide polymorphism rs3746444 in miR‑499a affects susceptibility to non‑small cell lung carcinoma by regulating the expression of CD200.

[PMID 30872409OA-icon.png] Impacts of Single Nucleotide Polymorphisms in three MicroRNAs (miR-146a, miR-196a2 and miR-499) on Susceptibility to Cervical Cancer among Indian Women.

[PMID 31496728OA-icon.png] Association of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AEG) risk and lymph node status.

[PMID 33145433OA-icon.png] MicroRNA-499 rs3746444 polymorphism in Egyptian children with biliary atresia.

[PMID 33230439OA-icon.png] miR-499 rs3746444 and miR-196a-2 rs11614913 Are Associated with the Risk of Glioma, but Not the Prognosis.

[PMID 33319237OA-icon.png] The correlation of microRNA-499 rs3746444 T>C locus with the susceptibility of gastric cancer: From a case-control study to a meta-analysis.