rs276174859

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Geno	Mag	Summary
(AG;TC)	6	BRCA2 variant considered pathogenic for breast cancer
(TC;TC)	0	common in clinvar

Make rs276174859(AG;AG)

Reference

GRCh38 38.1/141

Chromosome

13

Position

32339964

Gene

BRCA2

is a	snp
is	mentioned by
dbSNP	rs276174859
dbSNP (classic)	rs276174859
ClinGen	rs276174859
ebi	rs276174859
HLI	rs276174859
Exac	rs276174859
Gnomad	rs276174859
Varsome	rs276174859
LitVar	rs276174859
Map	rs276174859
PheGenI	rs276174859
Biobank	rs276174859
1000 genomes	rs276174859
hgdp	rs276174859
ensembl	rs276174859
geneview	rs276174859
scholar	rs276174859
google	rs276174859
pharmgkb	rs276174859
gwascentral	rs276174859
openSNP	rs276174859
23andMe	rs276174859
SNPshot	rs276174859
SNPdbe	rs276174859
MSV3d	rs276174859
GWAS Ctlg	rs276174859

Max Magnitude

6

rs276174859, also known as F1870X, c.5609_5610delTCinsAG and p.Phe1870Ter, is a variant in the BRCA2 gene considered pathogenic for breast cancer in ClinVar.

ClinVar
Risk	rs276174859(AG;AG)
Alt	rs276174859(AG;AG)
Reference	Rs276174859(TC;TC)
Significance	Pathogenic
Disease	Fanconi anemia Hereditary breast and ovarian cancer syndrome Breast-ovarian cancer Hereditary cancer-predisposing syndrome Tumor susceptibility linked to germline BAP1 mutations not provided
Variation	info
Gene	BRCA2
CLNDBN	Fanconi anemia, complementation group D1 Hereditary breast and ovarian cancer syndrome Breast-ovarian cancer, familial 2 Hereditary cancer-predisposing syndrome Tumor susceptibility linked to germline BAP1 mutations not provided
Reversed	0
HGVS	NC_000013.10:g.32914101_32914102delTCinsAG
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000009924.4, RCV000044694.4, RCV000113449.3, RCV000129595.2, RCV000214770.1, RCV000255347.1,