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From SNPedia

This SNP may be most notable for being a perfect proxy for rs138042437; both are considered markers for a haplotype associated with moderately increased risk for prostate cancer.

[PMID 24952954OA-icon.png] A Rare 8q24 SNP Predisposes North American Men to Prostate Cancer and Possibly More Aggressive Disease

[PMID 25187206] The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men [PMID 27262462] Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.