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From SNPedia

Geno Mag Summary
(C;C) 1.8 hypertension not a risk factor for sudden cardiac death
(C;G) 1.8 hypertension not a risk factor for sudden cardiac death
(G;G) 2.5 hypertension increases risk 3.75x for sudden cardiac death
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs187238
1000 genomesrs187238
GWAS Ctlgrs187238
Max Magnitude2.5

rs187238, also known as -137 G/C, is a SNP in the interleukin 18 IL18 gene.

Based on studying autopsies of 700 men in the Helsinki Sudden Death Study, there was a significant interaction between IL-18 genotype and hypertension impacting on the risk of sudden cardiac death (SCD) due to coronary heart disease (CHD). Among rs187238(G;G) homozygotes, hypertension was a major risk factor for SCD due to CHD (adjusted odds ratio 3.75, CI:1.78-7.91, p < 0.001) and hypertension also associated with larger coronary atherosclerotic plaque areas (p = 0.002) and the occurrence of complicated plaques (adjusted OR 8.38, CI: 2.39-29.33, p < 0.001). Among rs187238(C) allele carriers, hypertension was not a significant risk factor for CHD-related SCD or CAD and did not associate with the development of coronary atherosclerotic plaques.[PMID 19687159]

[PMID 19455410] Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response

[PMID 20331879OA-icon.png] Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis

[PMID 20097272] Interleukin-18 promoter polymorphisms and risk of ischemic stroke

[PMID 21241672] Interleukin-18 Promoter Polymorphisms and Risk of Parkinson's disease in a Han Chinese Population

[PMID 21470492] Interleukin-18 promoter polymorphisms in patients with systemic lupus erythematosus

[PMID 21510800] Association Between Promoter Variants of Interleukin-18 and Schizophrenia in a Han Chinese Population

[PMID 21611751] Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis

[PMID 22008665] The associations of IL-18 serum levels and promoter polymorphism with tacrolimus pharmacokinetics and hepatic allograft dysfunction in Chinese liver transplantation recipients

[PMID 21962565] Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

[PMID 22664470] Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma

[PMID 15896202] Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis.

[PMID 16078996OA-icon.png] Association study of functional genetic variants of innate immunity related genes in celiac disease.

[PMID 16443795] Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.

[PMID 16542373OA-icon.png] Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults.

[PMID 16759385OA-icon.png] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16909454OA-icon.png] NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia.

[PMID 17355643OA-icon.png] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

[PMID 17765248] Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study.

[PMID 17854431] Interleukin-18 gene polymorphisms and haplotypes in patients with oral lichen planus: a study in an ethnic Chinese cohort.

[PMID 17919265] Polymorphism of interleukin-18 promoter influences the onset of kidney graft function after transplantation.

[PMID 18043444] Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection.

[PMID 18599493] Promoter polymorphism of interleukin-18 in angiographically proven coronary artery disease.

[PMID 19073159] Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease.

[PMID 19178691OA-icon.png] Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery.

[PMID 19229765] Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis.

[PMID 19961892] Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients.

[PMID 20304021] Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders.

[PMID 20478055OA-icon.png] Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.

[PMID 20818961] Inflammatory mediators gene polymorphisms in preeclampsia.

[PMID 21840518] Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage.

[PMID 21969001OA-icon.png] Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

[PMID 22325058] Association of polymorphisms in interleukin-18 and interleukin-28B with Hepatitis B recurrence after liver transplantation in Chinese Han population.

[PMID 22386125] Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population.

[PMID 23153245OA-icon.png] Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis

[PMID 23546966] Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population

[PMID 24446726OA-icon.png] Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans

[PMID 23073298] The IL18 gene and Hashimoto thyroiditis in children.

[PMID 23238919] Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis.

[PMID 23302036] Gender-specific association of the interleukin 18 gene with symptomatic gallstone disease.

[PMID 23557801] Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients.

[PMID 23587914] Interleukin-18 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

[PMID 24969483] IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case-control studies

[PMID 25192895] Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis

[PMID 25446437] Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population

[PMID 25690033OA-icon.png] Genetic variant in interleukin-18 is associated with idiopathic recurrent miscarriage in chinese han population

[PMID 25712187] Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies

[PMID 26042207OA-icon.png] Association between interleukin-18 gene promoter (- 607C/A and - 137G/C) polymorphisms and chronic hepatitis C virus infections: A meta-analysis

[PMID 26041375] A gene-disease association study of IL18 in thyroid cancer: genotype and haplotype analyses

[PMID 26116895] Interleukin-18 promoter -607 C/A and -137 G/C polymorphisms and susceptibility to type 1 diabetes: A meta-analysis


[PMID 27470888] [Association between interleukin-18 gene polymorphisms and hepatocellular carcinoma caused by hepatitis B virus].

[PMID 27559091] Influence of cytokine gene polymorphisms on proinflammatory/anti-inflammatory cytokine imbalance in premature coronary artery disease.

[PMID 28580570] IL16 and IL18 gene polymorphisms in women with gestational diabetes.

[PMID 29061223] Association between donor and recipient Interleukin-18 gene polymorphisms and the risk of infection after liver transplantation.

[PMID 29129846] The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study.

[PMID 30059753] Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children.

[PMID 30208882OA-icon.png] Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis.

[PMID 30728751OA-icon.png] Inflammasome Genes' Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment.

[PMID 31301271] Lack of significant effect of interleukin-18 gene variants on tuberculosis susceptibility in the Polish population.

[PMID 31448710] Frequency of Inflammasome Nlrp1/Nlrp3 Gene Receptor Polimorphisms And The Interleukins IL-1ß/IL-18 Gene Polymorphisms And Their Association With Severity Score In Sickle Cell Disease Patients.

[PMID 31660404OA-icon.png] Impacts of Interleukin-18 Polymorphisms on the Incidence of Delayed-Onset Cytomegalovirus Infection in a Cohort of Kidney Transplant Recipients.

[PMID 32106113] Influence of Polymorphisms in the Interleukin-18 Gene on Allergic Rhinitis: A Meta-Analysis.

[PMID 32425678OA-icon.png] Polymorphisms of genes encoding cytokines predict the risk of high-grade bladder cancer and outcomes of BCG immunotherapy.

[PMID 31992083] IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study.