rs185386680
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | common/normal |
| (A;G) | 2.2 | carrier of one HLA-B*38:02:01 allele; avoid thioamide drugs |
| Make rs185386680(G;G) |
| Reference | GRCh38.p2 38.2/146 |
| Chromosome | 6 |
| Position | 31207153 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs185386680 |
| dbSNP (classic) | rs185386680 |
| ClinGen | rs185386680 |
| ebi | rs185386680 |
| HLI | rs185386680 |
| Exac | rs185386680 |
| Gnomad | rs185386680 |
| Varsome | rs185386680 |
| LitVar | rs185386680 |
| Map | rs185386680 |
| PheGenI | rs185386680 |
| Biobank | rs185386680 |
| 1000 genomes | rs185386680 |
| hgdp | rs185386680 |
| ensembl | rs185386680 |
| geneview | rs185386680 |
| scholar | rs185386680 |
| rs185386680 | |
| pharmgkb | rs185386680 |
| gwascentral | rs185386680 |
| openSNP | rs185386680 |
| 23andMe | rs185386680 |
| SNPshot | rs185386680 |
| SNPdbe | rs185386680 |
| MSV3d | rs185386680 |
| GWAS Ctlg | rs185386680 |
| Max Magnitude | 2.2 |
rs185386680(G) appears to be in complete linkage disequilibrium with the HLA-B*38:02:01 allele, and can therefore be used as a marker for it.[PMID 26599303]
The HLA-B*38:02:01 allele is associated with carbimazole/methimazole-induced agranulocytosis (OR=265.5, CI: 27.9-2528, p=2.5x10-e14), but not associated with propylthiouracil, so screening for the risk allele may be useful in preventing agranulocytosis in hyperthyroid patients potentially being treated with thioamides antithyroid-drugs, such as thioacetamide, methimazole, or carbimazole.[PMID 26599303]
