rs1801157
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.4 | 1.4x higher risk for breast cancer |
| (A;G) | 1.4 | 1.4x higher risk for breast cancer |
| (G;G) | 0 |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 44372809 |
| Gene | CXCL12 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1801157 |
| dbSNP (classic) | rs1801157 |
| ClinGen | rs1801157 |
| ebi | rs1801157 |
| HLI | rs1801157 |
| Exac | rs1801157 |
| Gnomad | rs1801157 |
| Varsome | rs1801157 |
| LitVar | rs1801157 |
| Map | rs1801157 |
| PheGenI | rs1801157 |
| Biobank | rs1801157 |
| 1000 genomes | rs1801157 |
| hgdp | rs1801157 |
| ensembl | rs1801157 |
| geneview | rs1801157 |
| scholar | rs1801157 |
| rs1801157 | |
| pharmgkb | rs1801157 |
| gwascentral | rs1801157 |
| openSNP | rs1801157 |
| 23andMe | rs1801157 |
| SNPshot | rs1801157 |
| SNPdbe | rs1801157 |
| MSV3d | rs1801157 |
| GWAS Ctlg | rs1801157 |
| GMAF | 0.208 |
| Max Magnitude | 1.4 |
rs1801157, also known as G801A, is a SNP in the chemokine (C-X-C motif) ligand 12 CXCL12 gene.
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1801157(A) was associated with protection against infection (OR=0.63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). [PMID 16177829] HIV-1/AIDS
A 2011 meta-analysis (comprising 5 studies totaling 1,058 cases) found that the rs1801157(A) allele was associated with higher risk for breast cancer, with an odds ratio of 1.44 (CI: 1.2 - 1.7; under a dominant model).[PMID 21643956]
[PMID 19601773] Molecular phenotype of CXCL12beta 3' UTR G801A polymorphism (rs1801157) associated to HIV-1 disease progression
[PMID 19788587
] Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control study
[PMID 19821058] Association of the SDF1-3'A polymorphism with susceptibility to myocardial infarction in Chinese Han population
[PMID 19927352] CXCL12 rs1801157 polymorphism in patients with breast cancer, hodgkin's lymphoma, and non-hodgkin's lymphoma
[PMID 20406099] CXCL12-3' G801A Polymorphism Is Not a Risk Factor for Breast Cancer
[PMID 22166550] Association of the-801G/A Polymorphism of CXCL12 Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population
[PMID 22699677] CXCL12, CXCR4 and IFNγ genes expression: implications for proinflammatory microenvironment of breast cancer
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
[PMID 17509149] Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
[PMID 17848170] The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.
[PMID 17982648] Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer.
[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19115008] SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19196101] Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19327121] Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19956101] Overview of the Rapid Response data.
[PMID 19956109] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
[PMID 20041166] Common genetic variation and the control of HIV-1 in humans.
[PMID 20725607] CCL3 genotype and current depression increase risk of HIV-associated dementia.
[PMID 21296802] Haplotype analysis of chemokine CXCL12 polymorphisms and susceptibility to premature ovarian failure in Chinese women.
[PMID 21304904] Genetic predisposition of donors affects the allograft outcome in kidney transplantation; polymorphisms of stromal-derived factor-1 and CXC receptor 4.
[PMID 21584490] SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.
[PMID 21592819] CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients.
[PMID 22962615] The Role of Genetic Variants of Stromal Cell-Derived Factor 1 in Pediatric HIV-1 Infection and Disease Progression
[PMID 23078136] Stromal-derived factor-1 gene variations in pediatric patients with primary immune thrombocytopenia
[PMID 23653000] CXCL12 and TP53 genetic polymorphisms as markers of susceptibility in a Brazilian children population with acute lymphoblastic leukemia (ALL)
[PMID 23711392] The CXCL12-3'A allele plays a favourable role in patients with multiple myeloma
[PMID 22939870] The CXCL12 G801A polymorphism and cancer risk: evidence from 17 case-control studies.
[PMID 24950177] A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients
[PMID 25029540] Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients
[PMID 25803672] Variant rs1801157 in the 3'UTR of SDF-1ß Does Not Explain Variability of Healthy-Donor G-CSF Responsiveness
[PMID 25800732] SDF1-3'A polymorphism is associated with size but not occurrence of abdominal aortic aneurysm in a Chinese population
[PMID 25839939] Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic foot ulcer
[PMID 26133117] Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis
[PMID 28929029] Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan and in-silico expression analysis of CXCL12-CXCR4 associated biological regulatory network.
[PMID 30009916] Single nucleotide polymorphisms in cytokine/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer.
[PMID 30253706] Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease.
