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From SNPedia

Geno Mag Summary
(A;A) 1.4 1.4x higher risk for breast cancer
(A;G) 1.4 1.4x higher risk for breast cancer
(G;G) 0
ReferenceGRCh38 38.1/142
is asnp
is mentioned by
dbSNP (classic)rs1801157
1000 genomesrs1801157
GWAS Ctlgrs1801157
Max Magnitude1.4

rs1801157, also known as G801A, is a SNP in the chemokine (C-X-C motif) ligand 12 CXCL12 gene.

? (A;A) (A;G) (G;G) 28

rs1801157(A) was associated with protection against infection (OR=0.63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). [PMID 16177829] HIV-1/AIDS

A 2011 meta-analysis (comprising 5 studies totaling 1,058 cases) found that the rs1801157(A) allele was associated with higher risk for breast cancer, with an odds ratio of 1.44 (CI: 1.2 - 1.7; under a dominant model).[PMID 21643956]

[PMID 19601773] Molecular phenotype of CXCL12beta 3' UTR G801A polymorphism (rs1801157) associated to HIV-1 disease progression

[PMID 19788587OA-icon.png] Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control study

[PMID 19821058] Association of the SDF1-3'A polymorphism with susceptibility to myocardial infarction in Chinese Han population

[PMID 19927352OA-icon.png] CXCL12 rs1801157 polymorphism in patients with breast cancer, hodgkin's lymphoma, and non-hodgkin's lymphoma

[PMID 20406099] CXCL12-3' G801A Polymorphism Is Not a Risk Factor for Breast Cancer

[PMID 22166550] Association of the-801G/A Polymorphism of CXCL12 Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population

[PMID 22699677] CXCL12, CXCR4 and IFNγ genes expression: implications for proinflammatory microenvironment of breast cancer

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17509149OA-icon.png] Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.

[PMID 17848170OA-icon.png] The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.

[PMID 17982648] Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer.

[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19115008OA-icon.png] SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19196101] Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19327121] Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19956101OA-icon.png] Overview of the Rapid Response data.

[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20041166OA-icon.png] Common genetic variation and the control of HIV-1 in humans.

[PMID 20725607OA-icon.png] CCL3 genotype and current depression increase risk of HIV-associated dementia.

[PMID 21296802] Haplotype analysis of chemokine CXCL12 polymorphisms and susceptibility to premature ovarian failure in Chinese women.

[PMID 21304904OA-icon.png] Genetic predisposition of donors affects the allograft outcome in kidney transplantation; polymorphisms of stromal-derived factor-1 and CXC receptor 4.

[PMID 21584490] SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.

[PMID 21592819] CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients.

[PMID 22962615OA-icon.png] The Role of Genetic Variants of Stromal Cell-Derived Factor 1 in Pediatric HIV-1 Infection and Disease Progression

[PMID 23078136] Stromal-derived factor-1 gene variations in pediatric patients with primary immune thrombocytopenia

[PMID 23653000] CXCL12 and TP53 genetic polymorphisms as markers of susceptibility in a Brazilian children population with acute lymphoblastic leukemia (ALL)

[PMID 23711392] The CXCL12-3'A allele plays a favourable role in patients with multiple myeloma

[PMID 22939870] The CXCL12 G801A polymorphism and cancer risk: evidence from 17 case-control studies.

[PMID 24950177OA-icon.png] A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients

[PMID 25029540OA-icon.png] Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients

[PMID 25803672OA-icon.png] Variant rs1801157 in the 3'UTR of SDF-1ß Does Not Explain Variability of Healthy-Donor G-CSF Responsiveness

[PMID 25800732] SDF1-3'A polymorphism is associated with size but not occurrence of abdominal aortic aneurysm in a Chinese population

[PMID 25839939] Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic foot ulcer

[PMID 26133117OA-icon.png] Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis

[PMID 28929029OA-icon.png] Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan and in-silico expression analysis of CXCL12-CXCR4 associated biological regulatory network.

[PMID 30009916] Single nucleotide polymorphisms in cytokine/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer.

[PMID 30253706] Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease.