rs1800925

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Geno	Mag	Summary
(C;C)	0	common/normal

Make rs1800925(C;T)

Make rs1800925(T;T)

Reference

GRCh38 38.1/141

Chromosome

5

Position

132657117

Gene	IL13, TH2LCRR

is a	snp
is	mentioned by
dbSNP	rs1800925
dbSNP (classic)	rs1800925
ClinGen	rs1800925
ebi	rs1800925
HLI	rs1800925
Exac	rs1800925
Gnomad	rs1800925
Varsome	rs1800925
LitVar	rs1800925
Map	rs1800925
PheGenI	rs1800925
Biobank	rs1800925
1000 genomes	rs1800925
hgdp	rs1800925
ensembl	rs1800925
geneview	rs1800925
scholar	rs1800925
google	rs1800925
pharmgkb	rs1800925
gwascentral	rs1800925
openSNP	rs1800925
23andMe	rs1800925
SNPshot	rs1800925
SNPdbe	rs1800925
MSV3d	rs1800925
GWAS Ctlg	rs1800925

GMAF

0.2406

Max Magnitude

0

asthma related [PMID 17561245]

This SNP is in the promoter region of the IL-13 gene

PMID: 17615386 IL-13 is involved in pulmonary inflammation, remodeling and susceptibility to chronic obstructive pulmonary disease (COPD). This IL13 promoter polymorphism may modulate the adverse effects of cigarette smoking on pulmonary function in long-term cigarette smokers. Every 20 pack-year increment in smoking was associated with a 2.4% reduction in mean ppFEV1(forced expiratory volume in 1 second, a measure used to assess lung disease, like COPD) in the common homozygous (CC) or heterozygous (CT) promoter genotypes, and an 8.2% reduction in mean ppFEV1 in minor allele homozygotes (TT, recessive model).

pack-year= packs per day x years smoked

[PMID 18614543 ] rs1800925 and/or rs11568506 related to psoriasis and/or Crohn's disease ?

[PMID 18273035] rs324013 and rs1800925 influence transcription factor binding. These results are consistent with the Th2 cytokine pathway enhancing resistance to schistosome infection.

[PMID 19254294] Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.

[PMID 19471606 ] Recent advances in the characterization of genetic factors involved in human susceptibility to infection by schistosomiasis

[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial

[PMID 19796199] Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease [PMID 19840389 ] Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria

[PMID 20403202 ] Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study

[PMID 19968631] Gene-gene and gene-environment interactions on IgE production in prenatal stage

[PMID 20975284] Case-Control Study of Eczema Associated with IL13 Genetic Polymorphisms in Japanese Children

[PMID 21050946 ] Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE

[PMID 20484924] Interleukin 13 and interleukin 4 receptor-? polymorphisms in rhinitis and asthma

[PMID 21309855 ] A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis

[PMID 22013915 ] IL13 genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan

[PMID 22023794 ] Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

[PMID 22053598] Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population

[PMID 22432974] Environmental tobacco smoke and male sex modify the influence of IL-13 genetic variants on cord blood IgE levels

[PMID 22750299] Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: A meta-analysis based on 1,411 cases and 3,169 controls

[PMID 15660293 ] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

[PMID 15726497 ] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16024651 ] Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.

[PMID 16091150 ] Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes.

[PMID 16449530 ] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 16832637] Evaluation of interleukin 13 polymorphisms in systemic sclerosis.

[PMID 17142763] Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation.

[PMID 17303794 ] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

[PMID 17327408 ] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17346294 ] IL13 gene polymorphism association with cord serum immunoglobulin E.

[PMID 17705862 ] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18006935] An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.

[PMID 18037162 ] Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort.

[PMID 18056382 ] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.

[PMID 18075513] Variants in the 5q31 cytokine gene cluster are associated with psoriasis.

[PMID 18186920 ] IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.

[PMID 18410415 ] Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.

[PMID 18625055 ] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

[PMID 18633131 ] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870 ] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755 ] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 18846228 ] Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.

[PMID 19066394 ] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19356949 ] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19554022] Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking.

[PMID 19759553 ] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.

[PMID 19956101 ] Overview of the Rapid Response data.

[PMID 19956109 ] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20015396 ] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

[PMID 20358028 ] IL-13 Gene Polymorphisms are Associated With Rhinosinusitis and Eosinophilic Inflammation in Aspirin Intolerant Asthma.

[PMID 20418110 ] Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer.

[PMID 20444268 ] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.

[PMID 20606885 ] Genetics of psoriasis and psoriatic arthritis.

[PMID 20644561] A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.

[PMID 20811626 ] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20861864] Association of rs7719175, located in the IL13 gene promoter, with Schistosoma haematobium infection levels and identification of a susceptibility haplotype.

[PMID 21071541 ] Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster.

[PMID 21320344 ] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

[PMID 21349879 ] Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.

[PMID 21613309] IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients.

[PMID 21649724] Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi-ethnic country.

[PMID 22045834] Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.

[PMID 22222605] IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis.

[PMID 23668806 ] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

[PMID 23299779 ] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma

[PMID 23886125] Interleukin 10 rs1800872 T>G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population

[PMID 24286397] Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population: a case-control study

[PMID 23246181] Association between IL13 gene polymorphisms and susceptibility to cancer: a meta-analysis.

[PMID 23549736] Association of the SNP rs1800925(C/T) in the interleukin-13 gene promoter with pulmonary function in Chinese Han patients with idiopathic pulmonary fibrosis.

[PMID 25658755 ] Association between Polymorphism of the Interleukin-13 Gene and Susceptibility to Hepatocellular Carcinoma in the Chinese Population

[PMID 26258681 ] An IL-13 Promoter Polymorphism Associated with Liver Fibrosis in Patients with Schistosoma japonicum

[PMID 26365633] Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese

[PMID 26387812 ] Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma

[PMID 29381928 ] Association of the IL-13 polymorphisms rs1800925 and rs20541 with chronic obstructive pulmonary disease risk: An updated meta-analysis.

[PMID 29687183] Single nucleotide polymorphisms of IL-13 and CD14 genes in allergic rhinitis: a meta-analysis.

[PMID 30227113] Association study on IL-4, IL-4Rα and IL-13 genetic polymorphisms in Swedish patients with colorectal cancer.

[PMID 30601841 ] Genetic variants in genes related to inflammation, apoptosis and autophagy in breast cancer risk.

[PMID 31845023] Genetic polymorphism patterns suggest a genetic driven inflammatory response as pathogenesis in appendicitis.

[PMID 31900992] Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population.

[PMID 33175217] Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India.

[PMID 33191717] Interleukin 13 gene polymorphism and susceptibility to asthma: a meta-regression and meta-analysis.