|| Slight increase in breast cancer risk for pre-menopausal African women
In an analysis restricted to pre-menopausal women, there was a per allele odds ratio associated with breast cancer of 1.72 (CI: 1.08-2.76; p-value = 0.023) for rs1800371(T), a functional polymorphism in the TP53 gene. Although this (Pro47Ser) variant was not associated with overall breast cancer risk, it may increase risk among pre-menopausal women of African ancestry.[PMID 28649645]
|?|| (C;C) (C;T) (T;T) ||28|
] Investigation of genetic polymorphisms related to the outcome of radiotherapy for prostate cancer patients
[PMID 18212354] Genes in glucose metabolism and association with spina bifida.
[PMID 18798306] Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population.
[PMID 19784392] Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism.
[PMID 25935255] TP53 polymorphism may contribute to genetic susceptibility to develop Hashimoto's thyroiditis
[PMID 28649645] A functionally significant SNP in TP53 and breast cancer risk in African-American women.