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From SNPedia

risk for prostate cancer
Geno Mag Summary
(A;A) 2.9 1.5x increased risk for prostate cancer
(A;C) 2.9 1.5x increased risk for prostate cancer
(C;C) 0 normal risk
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs16901979
1000 genomesrs16901979
GWAS Ctlgrs16901979
Max Magnitude2.9
? (A;A) (A;C) (C;C) 28

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This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

rs16901979 is a SNP on chromosome 8q24, associated with increased risk for prostate cancer in several studies. In some studies, the regions have been divided, and this SNP falls in region 2.

In a study of over 3,600 Caucasians with prostate cancer, rs16901979 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs16901979(A;A) and (A;C) risk genotypes yield an odds ratio for developing prostate cancer of 1.53 (CI: 1.22-1.92, p=1.8x10e-4) and may account for 3.6% of population attributable risk.10.1056/NEJMoa075819

cancer related according to this blog

Two genetic markers in the 8q24 region of chromosome 8 rs7008482 and rs16901979 have been linked to an increased risk of prostate cancer in African Americans. abstract

In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 2) of advanced prostate cancer.[PMID 18231127OA-icon.png]

A meta-analysis of 10+ studies comprising over 15,000 prostate cancer patients concluded that the odds ratio for rs16901979(A) allele carriers is 1.74 (CI: 1.72-1.77).[PMID 18231127OA-icon.png]

SNP rs16901979
PubMedID [PMID 17401366]
Condition Prostate cancer
Gene Intergenic
Risk Allele A
pValue 1.00E-012
OR 1.79
95% CI 1.53-2.11) (EA

[PMID 19549807OA-icon.png] Prostate Cancer Risk Associated Loci in African Americans

[PMID 19562729OA-icon.png] Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry

GWAS snp
PMID [PMID 19767754OA-icon.png]
Trait Prostate cancer
Title Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
Risk Allele A
P-val 3E-14
Odds Ratio 1.80 [1.55-2.09]

[PMID 19908238] Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men

[PMID 20564319OA-icon.png] Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation

[PMID 20717903OA-icon.png] Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men's health study

[PMID 21229559] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry

[PMID 21820706OA-icon.png] Prostate Cancer Risk Alleles and Their Associations With Other Malignancies

[PMID 21756274OA-icon.png] Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men

[PMID 22067658OA-icon.png] Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders

[PMID 22234922OA-icon.png] 8q24 risk alleles in West African and Caribbean men

[PMID 22303333OA-icon.png] Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans

[PMID 22583965] Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population

[PMID 17978284OA-icon.png] Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus.

[PMID 18213635] Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.

[PMID 18274536OA-icon.png] Genome-wide association studies: progress and potential for drug discovery and development.

[PMID 18360876OA-icon.png] Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.

[PMID 18423739] Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility alleles.

[PMID 18491292OA-icon.png] Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.

[PMID 18577746OA-icon.png] Multiple loci with different cancer specificities within the 8q24 gene desert.

[PMID 18670647OA-icon.png] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.

[PMID 18682823OA-icon.png] Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.

[PMID 18768484OA-icon.png] Family-based samples can play an important role in genetic association studies.

[PMID 18768513OA-icon.png] Common 8q24 sequence variations are associated with Asian Indian advanced prostate cancer risk.

[PMID 18794092OA-icon.png] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.

[PMID 18990762OA-icon.png] Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.

[PMID 19058137OA-icon.png] Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.

[PMID 19104501OA-icon.png] Prostate cancer genomics: towards a new understanding.

[PMID 19434657OA-icon.png] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.

[PMID 19520795OA-icon.png] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.

[PMID 19528667OA-icon.png] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.

[PMID 19602258OA-icon.png] Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.

[PMID 20039378OA-icon.png] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.

[PMID 20133699OA-icon.png] Long-range enhancers on 8q24 regulate c-Myc.

[PMID 20584312OA-icon.png] 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.

[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.

[PMID 20823317OA-icon.png] is-rSNP: a novel technique for in silico regulatory SNP detection.

[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.

[PMID 21445969] Significant associations of prostate cancer susceptibility variants with survival in patients treated with androgen-deprivation therapy.

[PMID 21455501OA-icon.png] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.

[PMID 21557270OA-icon.png] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry.

[PMID 22382457OA-icon.png] Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.

[PMID 22561070] 8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().

[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]

[PMID 24345439OA-icon.png] Prostate cancer risk alleles are associated with prostate cancer tumor volume and prostate size

[PMID 22848662OA-icon.png] Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese.

[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.

[PMID 25252079OA-icon.png] 8q24 risk alleles and prostate cancer in African-Barbadian men

[PMID 25684153] A simple-to-use method incorporating genomic markers into prostate cancer risk prediction tools facilitated future validation

[PMID 32341752OA-icon.png] Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer.

[PMID 32295536OA-icon.png] Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.