|risk for prostate cancer|
|(A;A)||2.9||1.5x increased risk for prostate cancer|
|(A;C)||2.9||1.5x increased risk for prostate cancer|
|?||(A;A) (A;C) (C;C)||28|
This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
rs16901979 is a SNP on chromosome 8q24, associated with increased risk for prostate cancer in several studies. In some studies, the regions have been divided, and this SNP falls in region 2.
In a study of over 3,600 Caucasians with prostate cancer, rs16901979 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs16901979(A;A) and (A;C) risk genotypes yield an odds ratio for developing prostate cancer of 1.53 (CI: 1.22-1.92, p=1.8x10e-4) and may account for 3.6% of population attributable risk.10.1056/NEJMoa075819
cancer related according to this blog
Two genetic markers in the 8q24 region of chromosome 8 rs7008482 and rs16901979 have been linked to an increased risk of prostate cancer in African Americans. abstract
In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 2) of advanced prostate cancer.[PMID 18231127]
A meta-analysis of 10+ studies comprising over 15,000 prostate cancer patients concluded that the odds ratio for rs16901979(A) allele carriers is 1.74 (CI: 1.72-1.77).[PMID 18231127]
|95% CI||1.53-2.11) (EA|
[PMID 19549807] Prostate Cancer Risk Associated Loci in African Americans
[PMID 19562729] Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry
|Title||Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility|
|Odds Ratio||1.80 [1.55-2.09]|
[PMID 19908238] Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men
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[PMID 20717903] Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men's health study
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[PMID 21820706] Prostate Cancer Risk Alleles and Their Associations With Other Malignancies
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[PMID 22067658] Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders
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[PMID 22303333] Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans
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[PMID 18670647] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
[PMID 18682823] Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.
[PMID 18768484] Family-based samples can play an important role in genetic association studies.
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[PMID 19520795] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
[PMID 19528667] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.
[PMID 19602258] Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 20133699] Long-range enhancers on 8q24 regulate c-Myc.
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[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.
[PMID 20823317] is-rSNP: a novel technique for in silico regulatory SNP detection.
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
[PMID 21445969] Significant associations of prostate cancer susceptibility variants with survival in patients treated with androgen-deprivation therapy.
[PMID 21455501] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
[PMID 21557270] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry.
[PMID 22382457] Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.
[PMID 22561070] 8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().
[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
[PMID 24345439] Prostate cancer risk alleles are associated with prostate cancer tumor volume and prostate size
[PMID 22848662] Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese.
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 25252079] 8q24 risk alleles and prostate cancer in African-Barbadian men
[PMID 25684153] A simple-to-use method incorporating genomic markers into prostate cancer risk prediction tools facilitated future validation
[PMID 32341752] Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer.
[PMID 32295536] Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.