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From SNPedia

Geno Mag Summary
(A;A) 3x risk
(A;G) 3x risk
(G;G) normal
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (old)rs1570360
1000 genomesrs1570360
23andMe allrs1570360
SNP Nexus

GWAS Ctlgrs1570360
Max Magnitude
This position is referred to as the -1154 position in many VEGF-associated publications. The normal (or wild type) form of this SNP is a (G). The (A) form reduces the activity of this gene, resulting in less VEGF protein.

Individuals with one or more rs1570360(A) alleles are reported to be at about a 3 fold higher risk of developing Sudden Infant Death Syndrome [PMID 16916659].

[PMID 19429179] Association between promoter polymorphisms of vascular endothelial growth factor gene and sporadic Alzheimer's disease among Northern Chinese Han

[PMID 19308252OA-icon.png] Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation

[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer

[PMID 20082870] A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation

[PMID 19233472] Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection

[PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population

[PMID 20678803] Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration

[PMID 20950367] Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Recurrent Spontaneous Abortion in Chinese Han Women

[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study

[PMID 22167330] Polymorphism of vascular endothelial growth factor -1154G>A (rs1570360) with cancer risk: a meta-analysis of 16 case-control studies

[PMID 22818823] Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients

[PMID 16142870] A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.

[PMID 16216669] Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.

[PMID 16395752] Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura.

[PMID 16613616OA-icon.png] Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

[PMID 16685110] Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.

[PMID 16801663] Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS.

[PMID 17204151OA-icon.png] VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.

[PMID 17319747OA-icon.png] Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

[PMID 17625508] VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies.

[PMID 18441306] VEGF polymorphisms are associated with severity of diabetic retinopathy.

[PMID 19551141OA-icon.png] Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.

[PMID 19587357OA-icon.png] A systematic meta-analysis of genetic association studies for diabetic retinopathy.

[PMID 19603096OA-icon.png] An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.

[PMID 19755511OA-icon.png] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

[PMID 19842071] No association of VEGF polymorphims with Alzheimer's disease.

[PMID 20140301] VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20444917] Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy.

[PMID 20706635OA-icon.png] Human genetics of diabetic retinopathy: current perspectives.

[PMID 21080079] Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.

[PMID 21257617] Association of polymorphisms/haplotypes of the genes encoding vascular endothelial growth factor and its KDR receptor with recurrent pregnancy loss.

[PMID 21347390OA-icon.png] Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

[PMID 21388351] Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients.

[PMID 21982816] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.

[PMID 23211130] Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage

[PMID 23404364] Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity

[PMID 24177231] The RTK/ERK Pathway is associated with Prostate Cancer Risk on the SNP level: a pooled analysis of 41 sets of data from case-control studies

[PMID 24321896] Effect of Genetic Polymorphisms of Vascular Endothelial Growth Factor on Left Ventricular Hypertrophy in Patients With Systemic Hypertension

[PMID 22729570] AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.

[PMID 22925497] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.

[PMID 23007311] VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction.

[PMID 23545315] Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.

[PMID 23553563] VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.

[PMID 24868559OA-icon.png] The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

[PMID 24935327] Haplotype Analysis on Chromosome 6p of Tumor Necrosis Factor Alpha, Vascular Endothelial Growth Factor A, and Interleukin-17F Alleles Associated With Corneal Transplant Rejection

[PMID 24940484OA-icon.png] Association between vascular endothelial growth factor gene polymorphisms and bladder cancer risk

[PMID 25148899] Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study

[PMID 25894981] Genetic Variations of VEGF Gene Were Associated with Tetralogy of Fallot Risk in a Chinese Han Population

[PMID 26002049] Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril

[PMID 26264619] Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers

[PMID 26305668] The Relationship between Vascular Endothelial Growth Factor 1154G/A Polymorphism and Recurrent Implantation Failure

[PMID 26486233] Vascular endothelial growth factor (VEGF)-634G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level

[PMID 28651127] Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia: A case-control study.

[PMID 27766947OA-icon.png] Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.