Geno
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Mag
|
Summary
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(A;A)
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0
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common/normal
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(A;G)
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4
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Possibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorder
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(G;G)
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4
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Possibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorder
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rs142787485 represents a rare variant in the RAB10 gene on chromosome 2.
A 2017 publication reports that the rs142787485(G) allele may be associated with a lower odds of developing Alzheimer's disease in individuals otherwise at higher risk for the disorder. In ~400 individuals from the ADNI cohort tested, the rs142787485(G) allele carriers had an odds ratio of 0.58 (p value = 0.018) compared to non-carriers; in ~500 individuals from the CCS cohort tested, rs142787485(G) carriers had an odds ratio of 0.69 (CI:0.47–0.99; p value 0.028). Another SNP, rs7653,
showed a similar protective effect but did not replicate in a second population tested.[PMID 29183403
]
The 2017 publication describes the same research cited in a report from ICAD 2016 (page 4 and page 9 of this pdf.