rs12007229

plus

Geno	Mag	Summary
(C;C)	0	Increased risk for incident vascular dementia

Make rs12007229(A;A)

Make rs12007229(A;C)

Reference

GRCh38 38.1/141

Chromosome

X

Position

67528513

is a	snp
is	mentioned by
dbSNP	rs12007229
dbSNP (classic)	rs12007229
ClinGen	rs12007229
ebi	rs12007229
HLI	rs12007229
Exac	rs12007229
Gnomad	rs12007229
Varsome	rs12007229
LitVar	rs12007229
Map	rs12007229
PheGenI	rs12007229
Biobank	rs12007229
1000 genomes	rs12007229
hgdp	rs12007229
ensembl	rs12007229
geneview	rs12007229
scholar	rs12007229
google	rs12007229
pharmgkb	rs12007229
gwascentral	rs12007229
openSNP	rs12007229
23andMe	rs12007229
SNPshot	rs12007229
SNPdbe	rs12007229
MSV3d	rs12007229
GWAS Ctlg	rs12007229

GMAF

0.101

Max Magnitude

0

?

(A;A) (A;C) (C;C)

28

rs12007229 is located on the X chromosome near the androgen receptor gene.

In a genome-wide association study of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3±3.2 years. The rs12007229(A) allele was associated with this development (odds ratio 3.7, CI: 2.3-5.8, p = 1.3×10e-8). The association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024).[PMID 22116812]

[PMID 15570555 ] Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.

[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.