Have questions? Visit https://www.reddit.com/r/SNPedia

Nicotine dependence

From SNPedia

Nicotine dependence, or smoking quantity, has been associated with numerous SNPs, including:

  • [PMID 18434921] Finds SNPs in both the DRD4 and DRD2 genes to be correlated to nicotine dependence in adolescents
  • [PMID 17888884] 2008 review of the pharmacogenetics of nicotine dependence and treatment
  • [PMID 17407593] SNPs associated with nicotine dependence seem to be roughly the same ones involved in multiple other substance dependencies
  • [PMID 16770336] A study of 400+ Israeli female subjects indicated that those homozygous for the HTR6-C276T C allele showed significantly increased risk of smoking initiation if they had experienced trauma.