Chlorpropamide is a drug in the sulfonylurea class used to treat type-2 diabetes. It is a long-acting first-generation sulfonylurea. It has more side effects than other sulfonylureas and its use is no longer recommended.Wikipedia
The FDA-approved drug label for chlorpropamide (Diabinese) states that caution should be used in patients with G6PD-deficiency due to the risk for hemolytic anemia, and that a non-sulfonylurea alternative should be considered for such patients.
|Genotype/Genoset||Diplotype||Gene||Drug Use/Category/Class||Medical Field||Summary||Descriptive Sentence|
|gs309||WT/WT||G6PD||Diabetes||Endocrinology||Normal Response Expected||You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia).|
|gs307||Carrier||G6PD||Diabetes||Endocrinology||Consider Alternatives||You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking chlorpropamide ; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable.|
|gs308||G6PD-deficient||G6PD||Diabetes||Endocrinology||Consider Alternatives||You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking chlorpropamide; non-sulfonylurea alternatives should be considered.|