Have questions? Visit https://www.reddit.com/r/SNPedia


From SNPedia

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. First approved by FDA under the trade name Zyloprim in 1966, it is now a generic drug sold under a variety of brand names, including Allohexal, Allosig, Milurit, Alloril, Progout, Zyloprim, Zyloric, Zyrik, and Aluron.Wikipedia

Allopurinol is contraindicated in individuals with a HLA-B*5801 variant allele due to significantly increased risk of severe cutaneous adverse reactions (SCAR), which includes drug hypersensitivity syndrome, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).