From SNPedia
rs9272346 has been reported in a large study to be associated with
type-1 diabetes.
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 5.49 (CI 4.83-6.24), and for homozygotes, 18.52 (CI 12.69-27.03). [PMID 17554300]
Note that the (A) allele is the most common in various human populations; instead of labeling (A) as a risk allele, we could consider the (G) allele protective.
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 18978792]
|
| Trait
| Type 1 diabetes
|
| Title
| Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
|
| Risk Allele
| G
|
| P-val
| 6E-129
|
| Odds Ratio
| NR NR
|
| PharmGKB | PA162355906 |
| Name | |
| Annotation | A genome-wide association study in 2,000 individuals for each of 7 major diseases and a shared set of 3,000 controls found an association of this SNP with type 1 diabetes. |
| Gene | HLA-DQA1 |
| Featue | |
| Evidence | PubMed ID:17554300 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 1 |
| Curation Level | Curated |
