Rs8702

From SNPedia
Jump to: navigation, search

Orientationminus
Geno Mag Summary
(C;C) average
(C;G)  ?
(G;G) 0.2x risk for MS
ReferenceGRCh38 38.1/141
Chromosome14
Position103686015
GeneKLC1
is asnp
is mentioned by
dbSNPrs8702
Exacrs8702
PheGenIrs8702
nextbiors8702
hapmaprs8702
1000 genomesrs8702
hgdprs8702
ensemblrs8702
gopubmedrs8702
geneviewrs8702
scholarrs8702
googlers8702
pharmgkbrs8702
gwascentralrs8702
openSNPrs8702
23andMers8702
23andMe allrs8702
SNP Nexus

SNPshotrs8702
SNPdbers8702
MSV3drs8702
GMAF0.4431
? (C;C) (C;G) (G;G) 28

SNP rs8702, located in the KLC1 gene, has been reported to have a protective effect against the occurrence of multiple sclerosis. Specifically, the odds of a rs8702(G;G) individual - as oriented to the dbSNP entry, not as published - are reported to be 0.21 (CI: 0.018 - 0.88). [PMID 17999208]

A study of ~800 Swedish patients with Alzheimer's disease did not find an association to rs8702 independently, however, rs8702 interacted with ApoE4 carrier status in AD (p=0.006).[PMID 17611642]


[PMID 19911314] Kinesin Light Chain 1 Gene Haplotypes in Three Conformational Diseases

[PMID 17653041OA-icon.png] Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.

[PMID 19046961] Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension.