KLC1

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# SNPs8
 Max MagnitudeChromosome positionSummary
Rs12432907103,702,041
Rs1799796103,699,590
Rs28903081103,698,934
Rs77381814103,699,410
Rs8007903103,671,306
Rs861537103,700,738
Rs8615390103,699,416
Rs8702103,686,015


Variants in the kinesin light-chain 1 KLC1 gene has potentially been implicated in a wide variety of conditions, including Alzheimer's disease, multiple sclerosis, cataracts, and leukoaraiosis.


  • A study of 100 patients with Alzheimer's disease found an association with the C allele of the KCL1 intron 13 SNP, G56836, with odds ratio = 1.73, CI: 1.12-2.67, p = 0.012. No synergistic effects were found between the ApoE4 allele and KCL1 gene polymorphisms.[PMID 15364413]

SNPs observed in connection to leukoaraiosis (LA) include:

  • A SNP known as the G56836C variant, located in intron 13. An association analysis performed in 229 patients with LA found that the 56836(C;C) variant increased the risk of LA 7.76-fold in hypertensive smokers as compared with those not carrying this variant.[PMID 17917076, PMID 17977659]