KLC1
From SNPedia
| is a | gene |
| is | mentioned by |
| EntrezGene | 3831 |
| PheGenI | 3831 |
| VariationViewer | 3831 |
| dbSNP | 3831 |
| SADR | 3831 |
| HugeNav | 3831 |
| wikipedia | KLC1 |
| KLC1 | |
| gopubmed | KLC1 |
| EVS | KLC1 |
| HEFalMp | KLC1 |
| 23andMe | KLC1 |
| EVS | KLC1 |
| # SNPs | 5 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| Rs1799796 | 104,165,927 | ||
| Rs77381814 | 104,165,747 | ||
| Rs8007903 | 104,137,643 | ||
| Rs861539 | 0 0 |
104,165,753 104,165,753 |
|
| Rs8702 | 104,152,352 |
Variants in the kinesin light-chain 1 KLC1 gene has potentially been implicated in a wide variety of conditions, including Alzheimer's disease, multiple sclerosis, cataracts, and leukoaraiosis.
- rs8702: observed in connection to both multiple sclerosis and Alzheimer's disease
- A study of 100 patients with Alzheimer's disease found an association with the C allele of the KCL1 intron 13 SNP, G56836, with odds ratio = 1.73, CI: 1.12-2.67, p = 0.012. No synergistic effects were found between the ApoE4 allele and KCL1 gene polymorphisms.[PMID 15364413]
SNPs observed in connection to leukoaraiosis (LA) include:
- A SNP known as the G56836C variant, located in intron 13. An association analysis performed in 229 patients with LA found that the 56836(C;C) variant increased the risk of LA 7.76-fold in hypertensive smokers as compared with those not carrying this variant.[PMID 17917076, PMID 17977659]
