Rs7528684

From SNPedia

rs7528684 has been reported to be associated with rheumatoid arthritis in a Caucasian population, following reports of a similar association in a Japanese population. [PMID 16176992]

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for homozygotes, 2.30 (CI 1.64-3.23). [PMID 17179172]

In a study of 645 Caucasians from Southern Spain with multiple sclerosis, the rs7528684(G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007).[PMID 18313765]

In another report [PMID 15838509], a summary indicates the following regarding disease and odds ratio (OR)for rs7528684:

• for rheumatoid arthritis: OR = 2.15 (CI = 1.58–2.93), from 830 cases and 658 controls;
• for SLE: OR = 1.49 (CI = 1.16–1.92), from 564 cases;
• for Graves' disease : OR = 1.79 (CI = 1.34–2.39), from 351 cases;
• for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07–2.47), from 158 cases.

[PMID 18087673] rs7528684 rs3792876 and rs2268277 failed to showed a statistically significant association with rheumatoid arthritis

[PMID 18556175] rs7528684, rs11264799, rs945635 and rs3761959 were not associated with systemic lupus erythematosus (SLE) in a study of 248 Chinese Han patients.

[PMID 19438904] Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease