From SNPedia
| ? | (C;C) (C;T) (T;T) | 28 |
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NOTE: information for
rs1050152 was accidentally entered for this SNP,
rs3792876. Although the SNPs are in the same gene, the original reference does not specifically refer to
rs3792876 and the degree of linkage has not been confirmed.
rs1051052, a SNP in the SLC22A4 gene known as L503F, has been associated with an autoimmune disease, in this case, Crohn's disease, odds ratio = 2.1 (CI = 1.31–3.39, p = 0.002), based on a study of 203 cases and 200 controls. The risk allele is rs1050152(T).[PMID 15107849]
A nearby SNP in the promoter region of the SLC22A5 gene defines a haplotype along with rs3792876, with odds ratio reported as similar for either SNP or the haplotype.[PMID 15107849]
[PMID 18709696] rs2073838 and rs3792876 replicated for rheumatoid arthritis in Japanese, but not Caucasian populations.
[PMID 18087673] rs3792876 failed to showed a statistically significant association with rheumatoid arthritis
| PharmGKB | PA162191341 |
| Name | |
| Annotation | In a replication study in a Japanese population and a metaanalysis of 9 studies confirmed an association of this SNP in the SLC22A4 gene with rheumatoid arthritis in Japanese population. The associations in Caucasian studies were not significant. |
| Gene | SLC22A4 |
| Featue | |
| Evidence | PubMed ID:18709696 |
| Drugs | |
| Diseases | Arthritis, Rheumatoid |
| Curation Level | Curated |
