From SNPedia
[PMID 18047539] significant associations with rs1004819, rs7517847, and rs11209026. Having any CARD15 variant was associated with a significant risk for Crohn's disease (P < 0.0001).
[PMID 17508420] rs7517847 (P=4.9x10(-9), OR 0.65, 0.56-0.75), is statistically independent of rs11209026.
[PMID 18698678] Replicated reduced risk for Crohn's disease with the rs7517847(G) allele in a study of Italian patients, but not ulcerative colitis.
| ? | (G;G) (G;T) (T;T) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 17435756]
|
| Trait
| Crohn's disease
|
| Title
| Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
|
| Risk Allele
|
|
| P-val
| 3.0000000000000001E-12
|
| Odds Ratio
| NR NR
|
Related to INFLAMMATORY BOWEL DISEASE 17; IBD17
according to
omim 612261. See
also
Related to INTERLEUKIN 23 RECEPTOR; IL23R
according to
omim 607562. See
also
[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility
[PMID 19895338] The Association Between Interleukin-23 Receptor Gene Polymorphisms and Systemic Lupus Erythematosus
| PharmGKB | PA162356596 |
| Name | |
| Annotation | GWAS Results: A genome-wide association study identifies IL23R as an inflammatory bowel disease gene (Initial Sample Size: 547 cases, 548 controls; Replication Sample Size: 401 cases, 433 controls, 883 families, 1,119 affected offspring; Risk Allele: rs7517847-C). |
| Gene | IL23R |
| Featue | |
| Evidence | PubMed ID:17068223; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Inflammatory Bowel Diseases |
| Curation Level | Non-Curated |
[PMID 20157760] Interleukin-23 receptor genetic polymorphisms and Crohn's disease susceptibility: a meta-analysis
