Rs737267

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Orientationplus
Make rs737267(G;G)
Make rs737267(G;T)
Make rs737267(T;T)
ReferenceGRCh38 38.1/141
Chromosome4
Position9933120
GeneSLC2A9
is asnp
is mentioned by
dbSNPrs737267
PheGenIrs737267
nextbiors737267
hapmaprs737267
1000 genomesrs737267
hgdprs737267
ensemblrs737267
gopubmedrs737267
geneviewrs737267
scholarrs737267
googlers737267
pharmgkbrs737267
gwascentralrs737267
openSNPrs737267
23andMers737267
23andMe allrs737267
SNP Nexus

SNPshotrs737267
SNPdbers737267
MSV3drs737267
GMAF0.2557
Max Magnitude
? (G;G) (G;T) (T;T) 28
GWAS
SNP rs737267
PubMedID [PMID 18327257]
Condition Serum urate
Gene SLC2A9
Risk Allele C
pValue 3.00E-009
OR 0.88
95% CI NR) uM decrease in uric acid (females only


OMIM612076
DescHYPOURICEMIA, RENAL, 2; RHUC2
Variant
Relatedalso
OMIM606142
DescSOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
Variant
Relatedalso



[PMID 20589538] Variation in the Uric Acid Transporter Gene SLC2A9 and Its Association with AAO of Parkinson's Disease

DeCode reports that the rs737267(G;T) genotype is associated with 0.77 times the normal risk of gout, and the rs737267(G;G) genotype is associated with 1.25 times higher risk of gout. [PMID 18398472OA-icon.png]

OMIM606142
Desc
Variant0003
Relatedalso
[PMID 17997608OA-icon.png] The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.


[PMID 18606621OA-icon.png] SLC2A9--a fructose transporter identified as a novel uric acid transporter.


[PMID 19260141OA-icon.png] Genome-wide association study of biochemical traits in Korcula Island, Croatia.


[PMID 20162744OA-icon.png] Interactions between genetic variants in glucose transporter type 9 (SLC2A9) and dietary habits in serum uric acid regulation.


[PMID 20162745OA-icon.png] Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.


[PMID 20348110OA-icon.png] Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome.


GET Evidence
rs737267
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.328125
summary



[PMID 23272134OA-icon.png] Changes in uric acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish Obese Subjects Study


[PMID 24379826OA-icon.png] Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans