| ? | (G;G) (G;T) (T;T) | 28 |
|---|
 |
| GWAS
|
| SNP
|
rs737267
|
| PubMedID
|
[PMID 18327257]
|
| Condition
|
Serum urate
|
| Gene
|
SLC2A9
|
| Risk Allele
|
C
|
| pValue
|
3.00E-009
|
| OR
|
0.88
|
| 95% CI
|
NR) uM decrease in uric acid (females only
|
| OMIM | 606142 |
| Desc | SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER |
| Variant | |
| Related | also |
[PMID 20589538] Variation in the Uric Acid Transporter Gene SLC2A9 and Its Association with AAO of Parkinson's Disease
DeCode reports that the rs737267(G;T) genotype is associated with 0.77 times the normal risk of gout, and the rs737267(G;G) genotype is associated with 1.25 times higher risk of gout. [PMID 18398472]
[PMID 17997608] The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
[PMID 18606621] SLC2A9--a fructose transporter identified as a novel uric acid transporter.
[PMID 19260141] Genome-wide association study of biochemical traits in Korcula Island, Croatia.
[PMID 20162744] Interactions between genetic variants in glucose transporter type 9 (SLC2A9) and dietary habits in serum uric acid regulation.
[PMID 20162745] Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.
[PMID 20348110] Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome.
| GET Evidence
|
| rs737267
|
| aa_change
|
|
| aa_change_short
|
|
| impact
|
pathogenic
|
| qualified_impact
|
Insufficiently evaluated pathogenic
|
| overall_frequency
|
0.328125
|
| summary
|
|
