Rs713598

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is asnp
is mentioned by
dbSNPrs713598
hapmaprs713598
hgdprs713598
ensemblrs713598
gopubmedrs713598
scholarrs713598
googlers713598
pharmgkbrs713598
hgvbaseg2prs713598
medrefsnprs713598
23andMers713598
SNP Nexus

GeneTAS2R38
Chromosome7
Orientationminus
Position141673345
ReferenceGRCh37 37.1/131
GenotypeEffect
rs713598(C;C)can taste bitter
rs713598(C;G)can taste bitter
rs713598(G;G)possibly unable to taste bitter


Genotypes Magnitude Summary
Rs713598(C;C) 1.11.1 can taste bitter
Rs713598(C;G) 0.10.1 can taste bitter
Rs713598(G;G) 0.10.1 possibly unable to taste bitter
? (C;C) (C;G) (G;G) 28
rs713598 is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the taste of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like coffee and dark beers).

The rs713598(G) allele, in the orientation shown in dbSNP, is the "tasting" allele, and it is dominant to the "non-tasting" allele rs713598(C), so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one rs10246939(C) and one rs1726866(C) allele since, along with rs713598(G), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.[PMID 12595690]

Neighborrs1726866
Distance640
Related to TASTE RECEPTOR, TYPE 2, MEMBER 38; TAS2R38 according to omim 607751. See also