Rs6822844
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs6822844 |
| hapmap | rs6822844 |
| hgdp | rs6822844 |
| ensembl | rs6822844 |
| gopubmed | rs6822844 |
| scholar | rs6822844 |
| rs6822844 | |
| pharmgkb | rs6822844 |
| hgvbaseg2p | rs6822844 |
| medrefsnp | rs6822844 |
| 23andMe | rs6822844 |
| SNP Nexus |
| Chromosome | 4 |
| Orientation | plus |
| Position | 123728870 |
| Genotype | Effect |
|---|---|
| rs6822844(G;G)* | ? |
| rs6822844(G;T)* | ? |
| rs6822844(T;T)* | ? |
Also, of SNPs outside the HLA region, this SNP and one other (rs13119723) in the region of the IL21 gene showed the strongest association with celiac disease in a study of ~800 Caucasian patients and a meta-analysis of two further populations.[PMID 17558408]
| ? | (G;G) (G;T) (T;T) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs6822844 |
| PubMedID | [PMID 17558408] |
| Condition | Celiac disease |
| Gene | KIA1109,TENR,IL2,IL21 |
| Risk Allele | G |
| pValue | 1.00E-014 |
| OR | 1.59 |
| 95% CI | 1.41-1.75 |
[PMID 19302705] Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.
| GWAS snp | |
|---|---|
| PMID | [PMID 18311140] |
| Trait | Celiac disease |
| Title | Newly identified genetic risk variants for celiac disease related to the immune response |
| Risk Allele | C |
| P-val | 2.9999999999999998E-13 |
| Odds Ratio | 1.44 [1.30-1.58] |
[PMID 19455118] Novel Genetic Risk Markers for Ulcerative Colitis in the IL2/IL21 Region Are in Epistasis With IL23R and Suggest a Common Genetic Background for Ulcerative Colitis and Celiac Disease
[PMID 19471255] Novel Association of the Interleukin 2-Interleukin 21 Region With Inflammatory Bowel Disease
[PMID 19201773] Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
[PMID 19404967] Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis
| PharmGKB | PA162167935 |
| Name | |
| Annotation | This SNP was shown to be associated with Type I Diabetes and with Rheumatoid Arthritis in a Dutch population. There was a decreased frequency of the T allele in cases compared to controls. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17999365 |
| Drugs | |
| Diseases | Arthritis, Rheumatoid, Diabetes Mellitus, Type 1 |
| Curation Level | Curated |
[PMID 20184734] The 4q27 locus and familial prostate cancer risk
