Celiac disease

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Celiac disease, also known as gluten intolerance, is an autoimmune disorder of genetically predisposed individuals, provoked by gluten proteins in wheat and related foods. Wikipedia

SNPs associated with celiac disease:


Although the HLA-DQ2 and DQ8 haplotypes are associated with gluten intolerance, as a 2010 blog post indicates, the frequency of these haplotypes (20-30%) is much higher than the frequency of celiac disease (~1%), so perhaps the primary value of SNP testing in this context is to rule out the likelihood of gluten intolerance. In other words, if you are among the 70-80% of individuals who do not carry HLA-DQ2 and/or DQ8 haplotypes, you are quite likely (> 95%) to tolerate gluten and to not be at risk for celiac disease.