Rs6700125

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is asnp
is mentioned by
dbSNPrs6700125
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hgdprs6700125
ensemblrs6700125
gopubmedrs6700125
scholarrs6700125
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pharmgkbrs6700125
hgvbaseg2prs6700125
medrefsnprs6700125
23andMers6700125
SNP Nexus

Chromosome1
Orientationplus
Position59475384
GenotypeEffect
rs6700125(C;C)0.7x decreased risk for ALS
rs6700125(C;T)1.2x increased risk for ALS
rs6700125(T;T)1.76x increased risk for ALS


Genotypes Magnitude Summary
Rs6700125(C;C) 0.7x decreased risk for ALS
Rs6700125(C;T) 1.2x increased risk for ALS
Rs6700125(T;T) 1.76x increased risk for ALS
rs6700125 is one of 6 SNPs found upstream of an (uncharacterized) gene known as FLJ10986 that have been found to be overrepresented in patients with sporadic amyotrophic lateral sclerosis (ALS).

A genome-wide association study of 1,152 ALS patients determined an allelic odds ratio of 1.38 for the rs6700125(T) allele (CI: 1.16-1.65, p=0.00032). The genotypic odds ratio presented were 1.76 (CI: 1.22-2.55) and 1.2 (CI: 0.83-1.73) for homozygotes and heterozygotes, respectively.[PMID 17671248]

  • Note: this SNP is in strong linkage disequilibrium with rs6690993 (r2>0.8)

[PMID 19177248] A study involving a large case-control series from the Netherlands, Belgium, Sweden and Ireland (total: 1883 sporadic ALS patients and 2063 controls) found no significant association between sporadic ALS and the six previously reported associated SNPs, including this one.

? (C;C) (C;T) (T;T)


[PMID 19922138] Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis

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