Rs6690993

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is asnp
is mentioned by
dbSNPrs6690993
hapmaprs6690993
hgdprs6690993
ensemblrs6690993
gopubmedrs6690993
scholarrs6690993
googlers6690993
pharmgkbrs6690993
hgvbaseg2prs6690993
medrefsnprs6690993
23andMers6690993
SNP Nexus

Chromosome1
Orientationplus
Position59476569
GenotypeEffect
rs6690993(A;A)0.7x decreased risk for ALS
rs6690993(A;G)1.2x increased risk for ALS
rs6690993(G;G)1.7x increased risk for ALS


Genotypes Magnitude Summary
Rs6690993(A;A) 0.7x decreased risk for ALS
Rs6690993(A;G) 1.2x increased risk for ALS
Rs6690993(G;G) 1.7x increased risk for ALS
rs6690993 is one of 6 SNPs found upstream of an (uncharacterized) gene known as FLJ10986 that have been found to be overrepresented in patients with sporadic amyotrophic lateral sclerosis (ALS).

A genome-wide association study of 1,152 ALS patients determined an allelic odds ratio of 1.35 for the rs6690993(G) allele (CI: 1.13-1.62, p=3x10-4). This association was seen only in Caucasians upon replication and not in non-Caucasians. The genotypic odds ratio presented were 1.69 (CI: 1.16-2.47) and 1.2 (CI: 0.81-1.71) for homozygotes and heterozygotes, respectively.[PMID 17671248]

  • Note: this SNP is in strong linkage disequilibrium with rs6700125 (r2>0.8)

[PMID 19177248] A study involving a large case-control series from the Netherlands, Belgium, Sweden and Ireland (total: 1883 sporadic ALS patients and 2063 controls) found no significant association between sporadic ALS and the six previously reported associated SNPs, including this one.

? (A;A) (A;G) (G;G)
Related to AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1 according to omim 105400. See also


Related to FLJ10986 according to omim 611370. See also


[PMID 19922138] Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis

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