From SNPedia
rs663048 associated with
lung cancer
The homozygotes for the variant allele had more than a 3-fold risk compared with the wild-type homozygotes [combined odds ratio (OR), 3.32; 95% confidence interval (95% CI), 1.81-7.21]. Heterozygotes also had a significantly elevated risk of lung cancer from the combined replication studies with an OR of 1.15 (95% CI, 1.04-1.59). The effect remained significant after adjusting for age, gender, and pack-years of tobacco smoke.007;67(17):8406-11]. [PMID 17804757]
| ? | (G;G) (G;T) (T;T) |
|---|
 |
| Venter snp
|
| Source
| plos
|
| Gene
| SEZ6L
|
| allele
| T
|
| frequency
| 0.225
|
| sift
| AFFECT FUNCTION
|
| HuRef
| 1103691020349
|
| Disease Association
| SEZ6L is located in a 22q region, which is frequently deleted in small cell lung carcinomas (SCLCs) and advanced non- small cell lung carcinomas.
|
