From SNPedia
| Geno
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Mag
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Summary
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| (C;C)
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higher risk for RA
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| (C;T)
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higher risk for RA; better response to paroxetine as treatment for depression
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| (T;T)
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0
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average
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| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
, also known as C1354T or His452Tyr/H452Y, is a SNP in the serotonin 2A receptor
HTR2A gene.
Based on a study of 166 Caucasian patients being treated for depression with paroxetine, rs6314 heterozygotes were associated with better response. There was a significantly higher frequency of heterozygotes in the remitter and response groups in comparison to the non-remitter (odds ratio 7.50, p=0.002) and non-response groups (odds ratio 5.25, p=0.01).10.1038/sj.tpj.6500491
Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.
[PMID 19584773] Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort
- "Haplotype association analysis suggests that the haplotype CCGCA (at SNPs rs3125, rs6314, rs1923886, rs2224721 and rs2770296) is protective against bipolar disorder (P = 0.021, odds ratio 0.63) and the rarer haplotype CCACG confers risk to the disorder (P = 0.0065, odds ratio 3.08)."
| PharmGKB | PA162181130 |
| Name | HTR2A: C1354T |
| Annotation | In a study in a unipolar depressive population (n=166) this variant showed an association with remission and response following paroxetine therapy. HTR2A C1354T heterozygotes were significantly associated with improved response to paroxetine therapy. The SNP was also studied as a modifier of antidepressant response in a study in depressed patients (n=173) given a variety of antidepressant treatments with no association found, however another report found the HTR2A T1354 allele to be associated with response to fluoxetine. |
| Gene | HTR2A |
| Featue | |
| Evidence | PubMed ID:11311507; PubMed ID:15052272; PubMed ID:18253134 |
| Drugs | fluoxetine, paroxetine |
| Diseases | Depression |
| Curation Level | Curated |
[PMID 19647026] Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes
Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.[PMID 18712714]
| PharmGKB | PA162181131 |
| Name | HTR2A: His452Tyr |
| Annotation | This variant in the gene encoding the serotonin 2A receptor has been associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. |
| Gene | HTR2A |
| Featue | |
| Evidence | PubMed ID:14699448; PubMed ID:15891581; PubMed ID:18602445 |
| Drugs | |
| Diseases | |
| Curation Level | Curated |
