Rs6265

rs6265, also known as Val66Met, is a SNP in brain-derived neurotrophic factor BDNF gene. The more common G allele encodes the Val, while the A allele encodes Met.

[PMID 20042999] Met/A allele associated with introversion

The A allele may also be protective against depression when subjected to repeated defeat [PMID 17956738] g2b2mh blog

On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020]

Wired discusses the research as does spittoon.

[PMID 17293537] Alzheimer's disease risk for non ApoE4 carriers is affected by the heterozygous form of rs6265, as well as the diplotypes of rs6265, rs11030104, and rs2049045.

[PMID 18600033] Depressed patients who had (GA or AA) appeared to show a significantly increased risk of suicidal behaviour

[PMID 19209189] In 2 studies of British women, rs6265(A;A) women had a lower body mass index than rs6265(G) allele carriers, with the difference being -0.57-0.911 kg/m(2), depending on the study.

[PMID 19388013] BDNF, relative preference, and reward circuitry responses to emotional communication

GWAS snp
PMID	[PMID 19079260]
Trait	Body mass index
Title	Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Risk Allele	G
P-val	5E-10
Odds Ratio	4.58 [3.07-6.09] % SD

[PMID 19461660] No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

[PMID 19530966] Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis

[PMID 19603419] Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations

[PMID 20943059] Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms

[PMID 15940292] A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

[PMID 18286632] Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder

[PMID 19699537] Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent

[PMID 19925205] Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging

[PMID 20033742] Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population

[PMID 19895626] The effect of BDNF gene variants on asthma in German children

[PMID 20087404] Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study

[PMID 20147969] Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension

[PMID 20418890] Genome-wide meta-analyses identify multiple loci associated with smoking behavior

[PMID 20682308] The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder

[PMID 20456319] Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

[PMID 20702703] The Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networks

[PMID 20959432] BDNF and CGRP interaction: Implications in migraine susceptibility

[PMID 20966902] Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

[PMID 21188787] Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder

[PMID 20843981] Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children

[PMID 21300947] The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease

[PMID 21723144] Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore

[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area

[PMID 21527513] Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity

[PMID 21889574] Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder

[PMID 21980924] BDNF Val66Met and Cognition: All, None, or Some? A Meta-Analysis of the Genetic Association

[PMID 22033217] Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women

[PMID 22085476] Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene

[PMID 22127997] No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese

[PMID 22173577] Recapitulation of the Association of the Val66Met Polymorphism of BDNF Gene With BMI in Koreans

[PMID 22188054] Polymorphisms in the Brain Derived Neurotrophic Factor (BDNF) Gene Influence Memory and Processing Speed One Month After Brain Injury

[PMID 22194877] Brain Derived Neurotrophic Factor (BDNF) Expression Is Regulated by MicroRNAs miR-26a and miR-26b Allele-Specific Binding

[PMID 21641949] Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in an Armenian population

[PMID 21880305] The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response

[PMID 22548711] Association of BDNF Gene Polymorphism with Bipolar Disorders in Han Chinese Population