Rs6265
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs6265 |
| hapmap | rs6265 |
| hgdp | rs6265 |
| ensembl | rs6265 |
| gopubmed | rs6265 |
| scholar | rs6265 |
| rs6265 | |
| pharmgkb | rs6265 |
| hgvbaseg2p | rs6265 |
| medrefsnp | rs6265 |
| 23andMe | rs6265 |
| SNP Nexus |
| Gene | BDNF |
| Chromosome | 11 |
| Orientation | minus |
| Position | 27636492 |
| Genotype | Effect |
|---|---|
| rs6265(A;A) | depression resistant; lower BMI |
| rs6265(A;G) | modulates Alzheimer's risk |
| rs6265(G;G) | ? |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs6265(A;A) | 2.52.5 | introversion; depression resistant; impaired motor skills learning |
| Rs6265(A;G) | 2.42.4 | impaired motor skills learning? |
| Rs6265(G;G) | ? |
rs6265, also known as Val66Met, is a SNP in brain-derived neurotrophic factor BDNF gene. The more common G allele encodes the Val, while the A allele encodes Met.
[PMID 20042999] Met/A allele associated with introversion
The A allele may also be protective against depression when subjected to repeated defeat [PMID 17956738] g2b2mh blog
On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020]
Wired discusses the research as does spittoon.
[PMID 17293537] Alzheimer's disease risk for non ApoE4 carriers is affected by the heterozygous form of rs6265, as well as the diplotypes of rs6265, rs11030104, and rs2049045.
[PMID 18600033] Depressed patients who had (GA or AA) appeared to show a significantly increased risk of suicidal behaviour
[PMID 19209189] In 2 studies of British women, rs6265(A;A) women had a lower body mass index than rs6265(G) allele carriers, with the difference being -0.57-0.911 kg/m(2), depending on the study.
| Neighbor | rs8192466 |
| Distance | 191 |
| ? | (A;A) (A;G) (G;G) |
|---|---|
|
| |
[PMID 19388013] BDNF, relative preference, and reward circuitry responses to emotional communication
| GWAS snp | |
|---|---|
| PMID | [PMID 19079260] |
| Trait | Body mass index |
| Title | Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity |
| Risk Allele | G |
| P-val | 5E-10 |
| Odds Ratio | 4.58 [3.07-6.09] % SD |
[PMID 19461660] No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
[PMID 19530966] Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis
[PMID 19603419] Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations
[PMID 19699537] Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent
[PMID 19925205] Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging
| PharmGKB | PA162364070 |
| Name | BDNF:Val66Met |
| Annotation | In DNA from frontal-cortex brain tissue of a group of Schizophrenia, Bipolar Disorder and Control individuals, this SNP was found to be associated with methylation at CpG sites surrounding the gene. CC genotype was associated with a higher level of methylation. |
| Gene | BDNF |
| Featue | |
| Evidence | PubMed ID:18319075 |
| Drugs | |
| Diseases | |
| Curation Level | Curated |
[PMID 20033742] Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population
[PMID 19895626] The effect of BDNF gene variants on asthma in German children
[PMID 20087404] Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study
[PMID 20147969] Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension
