Rs6152

rs6152, located in the first exon of the androgen receptor AR gene located on the X chromosome, is highly indicative of the ability to develop male pattern baldness. The risk allele is (G). However, although it appears to be necessary for baldness to develop, other (as yet unknown) variations must also be present for baldness to actually occur. [PMID 11231320], [PMID 17256155]

Since this SNP is on the X chromosome, and affects a trait primarily seen only in males, a single allele is shown as representing the individual's genotype. However, baldness may also occur in females, presumably only in females homozygous for rs6152(G;G) and also harboring the (as yet unknown) additional variations required for baldness.

Note: The colorful and informative Figure 1 in [PMID 17256155] shows the probability of varying degrees of baldness as men age depending on whether they are rs6152(A) or rs6152(G).

Note: A subsequent study has found that rs1160312 may be an important additional variant acting in conjunction with rs6152 to influence baldness.

[PMID 15902657] baldness

• lowest P value of 2.1×10-12 for rs10521339
• family based rs938059 shows the lowest P value (4.03×10-6) (table 3)
• rs6152 (P=6.66×10-10)

[PMID 21981665] Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis