Rs5888
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs5888 |
| hapmap | rs5888 |
| hgdp | rs5888 |
| ensembl | rs5888 |
| gopubmed | rs5888 |
| scholar | rs5888 |
| rs5888 | |
| pharmgkb | rs5888 |
| hgvbaseg2p | rs5888 |
| medrefsnp | rs5888 |
| 23andMe | rs5888 |
| SNP Nexus |
| Gene | SCARB1 |
| Chromosome | 12 |
| Orientation | minus |
| Position | 123850700 |
| Genotype | Effect |
|---|---|
| rs5888(C;C) | normal |
| rs5888(C;T) | 3x higher risk for age-related macular degeneration |
| rs5888(T;T) | 1.6x higher risk for age-related macular degeneration |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs5888(C;C) | normal | |
| Rs5888(C;T) | 2.52.5 | 3x higher risk for age-related macular degeneration |
| Rs5888(T;T) | 1.6x higher risk for age-related macular degeneration |
rs5888 is a SNP in the scavenger receptor class B, member 1 SCARB1 gene.
In a case-control study of two Caucasian populations totaling 2,498 patients, rs5888(C;T) heterozygotes had an increased odds ratio of 2.9 (CI: 1.6-5.3, p<0.002) for age-related macular degeneration (ARMD) based on a pooled analysis. Subgroup analysis indicated that the odds ratio for exudative forms of ARMD was even higher (3.6; CI: 1.7-7.6, p>0.0015) for rs5888(C;T) heterozygotes. [PMID 19806217]
