From SNPedia
| Genotype | Effect |
|---|
| rs5882(A;A) | |
| rs5882(A;G) | lower risk of dementia and Alzheimer's disease |
| rs5882(G;G) | longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's. |
This SNP has been related to exceptional
long life. A study in
Ashkenazi Jews showed that individuals homozygotic for the G allele have significantly longer lifespans.
New research also indicates that G homozygotes have an average of 70% less risk of dementia and Alzheimer's disease. The study also found that heterozygotes have a lower risk of dementia and Alzheimer's disease but more study is needed to determine the risk reduction for heterozygotes. See Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein (CETP) Gene With Memory Decline and Incidence of Dementia and CETP Variant Linked to Slower Cognitive Decline and Reduced Dementia Risk [PMID 20068209].
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| PharmGKB | PA162361024 |
| Name | CETP:I405V |
| Annotation | Meta-analysis showed weak inverse association with coronary risk for the CETP:I450V allele. |
| Gene | CETP |
| Featue | Exon/NonSyn |
| Evidence | PubMed ID:18560005 |
| Drugs | |
| Diseases | Coronary Disease |
| Curation Level | Curated |
