From SNPedia
The rs56337013(T) allele defines the CYP2C19 variant known as CYP2C19*5.
This variant is quite rare (< 1% of Caucasians or Chinese), and leads to a poor metabolizer phenotype.
[PMID 10022751]
| PharmGKB | PA162356002 |
| Name | CYP2C19:1297C>T, R433W |
| Annotation | This variant is the defining SNP for CYP2C19*5 and contributes to the S-mephenytoin poor metabolizer phenotype in caucasians and chinese. The Arg433 to Trp mutation in the heme-binding region essentially abolishes CYP2C19 activity toward S-mephenytoin and tolbutamide. |
| Gene | CYP2C19 |
| Featue | Exon |
| Evidence | PubMed ID:10022751 |
| Drugs | mephenytoin, tolbutamide |
| Diseases | |
| Curation Level | Curated |
