From SNPedia
rs4242382 is one of 4 tightly linked SNPs in the "locus 1" region of 8q24 chromosomal region, which has been linked in several studies to prostate cancer, initially through rs1447295.[PMID 17925536]
In a study of 1,563 patients of European ancestry, the odds ratio for prostate cancer associated with risk genotypes of locus 1 were reported as 1.70 (CI: 1.39-2.07). Two other regions of chromosome 8q24 were also studied.[PMID 17925536]
[PMID 19366831] Genotyping 13 SNPs (including this one) in 1,308 Caucasian prostate cancer patients led to the conclusion that while none of the SNP associations were as significant as having a first-degree family history of the disease, they did replicate. In fact, for rs4242382, the risk estimate varied by family history.
[PMID 19767755] A joint-odds analysis indicates that rs4242382(A;A) individuals have increased prostate cancer odds of 3.15x or 1.77x if they are also carrying 2 or 1 rs620861(C) alleles, respectively.
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 18264096]
|
| Trait
| Prostate cancer
|
| Title
| Multiple loci identified in a genome-wide association study of prostate cancer
|
| Risk Allele
| A
|
| P-val
| 3E-19
|
| Odds Ratio
| 1.66 [1.47-1.87]
|
