Rs1447295

rs1447295 is a SNP on chromosome 8q24, associated with increased risk for prostate cancer in several studies.

In a study of over 3,600 Caucasians with prostate cancer, rs1447295 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs1447295(A;A) and (A;C) risk genotypes yield an odds ratio for developing prostate cancer of 1.22 (CI: 1.06-1.40, p=5.3x10-3) and may account for 5.4% of population attributable risk.10.1056/NEJMoa075819

[1] The rs1447295 location could be responsible for about seven percent of prostate cancer cases in white men of north European descent. Thus, taken together with rs6983267, these two genetic changes could account for as much as one quarter of prostate cancer cases in white men. The increased risk was observed for all age groups studied.

Another study, in this case of 1,563 patients of European ancestry, found 4 SNPs (including rs1447295) in this region of chromosome 8q24 (termed "locus 1") to be strongly linked and associated with prostate cancer. The other 3 SNPs are rs4242382, rs7017300, and rs7837688. The odds ratio for having a risk genotype at locus 1 is 1.70 (CI: 1.39-2.07), and increases if risk genotypes are present at "locus 2" (rs6983267) or "locus 3" (rs10086908).[PMID 17925536]

A meta-analysis of 10+ studies comprising over 15,000 prostate cancer patients concluded that the odds ratio for rs1447295(A) allele carriers is 1.42 (CI: 1.40-1.44).[PMID 18231127]

The allele of higher risk for prostate cancer is rs1447295(A).

[PMID 18726982] In a study of Japanese men, the rs1447295(A) allele was associated with susceptibility to prostate cancer (PC vs. non-PC: p = 0.041, OR 1.28, CI: 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, p = 0.013, OR 1.43, CI: 1.08-1.90).

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GWAS snp
PMID	[PMID 17401366]
Trait	Prostate cancer
Title	Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Risk Allele	A
P-val	5.9999999999999997E-18
Odds Ratio	1.60 [1.43-1.77]

GWAS snp
PMID	[PMID 17401363]
Trait	Prostate cancer
Title	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Risk Allele	A
P-val	2E-14
Odds Ratio	1.43 [1.29-1.59]

[PMID 19562729] Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry

[PMID 19602258] Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men

GWAS snp
PMID	[PMID 19767754]
Trait	Prostate cancer
Title	Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
Risk Allele	A
P-val	2E-19
Odds Ratio	1.58 [1.43-1.74]

[PMID 19900942] Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy

[PMID 19908238] Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men

[PMID 19952762] The rs1447295 and DG8S737 markers on chromosome 8q24 and cancer risk in the Polish population

[PMID 20639049] Association of SNP rs1447295 and Microsatellite Marker DG8S737 With Familial Prostate Cancer and High Grade Disease

[PMID 20700145] Genetic marker polymorphisms on chromosome 8q24 and prostate cancer in the Dutch population: DG8S737 may not be the causative variant

[PMID 21102338] Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer

[PMID 21229559] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry

[PMID 21756274] Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men

[PMID 21308149] Impact of genotyping on outcome of prostatic biopsies: a multicenter prospective study

[PMID 22067658] Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders

[PMID 22275265] Common genetic variants in the 8q24 region and risk of papillary thyroid cancer

[PMID 22583965] Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population