From SNPedia
Linked to bipolar disorder in one of the most comprehensive studies to date (2007).
Risk allele with reference to dbSNP orientation is reported to be (T), with either one or two copies leading to an odds ratio of 2 (CI 1.6-2.7). [PMID 17554300]
| GWAS
|
| SNP
| rs420259
|
| PubMedID
| [PMID 17554300]
|
| Condition
| Bipolar disorder
|
| Gene
| PALB2,NDUFAB1,DCTN5
|
| Risk Allele
| T
|
| pValue
| 6.00E-008
|
| OR
| 2.08
|
| 95% CI
| 1.60-2.71
|
| ? | (C;C) (C;T) (T;T) |
|---|
 |
Related to MAJOR AFFECTIVE DISORDER 4; MAFD4
according to
omim 611247. See
also
| PharmGKB | PA162356654 |
| Name | |
| Annotation | GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,868 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs420259-A). This variant is associated with bipolar disorder. |
| Gene | PALB2 |
| Featue | |
| Evidence | PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Bipolar Disorder |
| Curation Level | Non-Curated |
