From SNPedia
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
Linked to bipolar disorder in one of the most comprehensive studies in 2007. Risk allele with reference to dbSNP orientation is reported to be (T), with either one or two copies leading to an odds ratio of 2 (CI 1.6-2.7). [PMID 17554300]
Some replications, but in 2011 23andMe published as failed to replicate in 10.1371/journal.pone.0023473
| GWAS
|
| SNP
|
rs420259
|
| PubMedID
|
[PMID 17554300]
|
| Condition
|
Bipolar disorder
|
| Gene
|
PALB2,NDUFAB1,DCTN5
|
| Risk Allele
|
T
|
| pValue
|
6.00E-008
|
| OR
|
2.08
|
| 95% CI
|
1.60-2.71
|
| PharmGKB | PA162356654 |
| Name | |
| Annotation | GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,868 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs420259-A). This variant is associated with bipolar disorder. |
| Gene | PALB2 |
| Featue | |
| Evidence | PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Bipolar Disorder |
| Curation Level | Non-Curated |
[PMID 20872766] Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample
| GWAS snp
|
| PMID
|
[PMID 21254220]
|
| Trait
|
|
| Title
|
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
|
| Risk Allele
|
|
| P-val
|
9E-9
|
| Odds Ratio
|
None None
|
