rs4149584 is a SNP in the tumor necrosis factor receptor superfamily, member 1A TNFRSF1A gene.
A large study (~5,000 patients) found two SNPs in the TNFRSF1A gene that each (independently) increase risk for multiple sclerosis, rs1800693 and rs4149584. This SNP, rs4149584, was less common but was associated with more risk; the odds ratio is reported as 22.214.171.1248/ng.401
|Title||Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci|
|Odds Ratio||1.58 [1.15-2.17]|
[PMID 20430450] Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain
|Disease||TNF receptor-associated periodic fever syndrome (TRAPS)|
|CLNDBN||TNF receptor-associated periodic fever syndrome (TRAPS)|
|CLNSRC||ClinVar OMIM Allelic Variant Unité médicale des maladies autoinflammatoires|
[PMID 20405052] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
[PMID 11175303] Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance.
[PMID 23624563] TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.