Rs1800693

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is asnp
is mentioned by
dbSNPrs1800693
hapmaprs1800693
hgdprs1800693
ensemblrs1800693
gopubmedrs1800693
scholarrs1800693
googlers1800693
pharmgkbrs1800693
hgvbaseg2prs1800693
medrefsnprs1800693
23andMers1800693
SNP Nexus

GeneTNFRSF1A
Chromosome12
Orientationminus
Position6310269
GenotypeEffect
rs1800693(A;A)*?
rs1800693(A;G)*?
rs1800693(G;G)*?


rs1800693 is a SNP in the tumor necrosis factor receptor superfamily, member 1A TNFRSF1A gene.

A large study (~5,000 patients) found two SNPs in the TNFRSF1A gene that each (independently) increase risk for multiple sclerosis, rs1800693 and rs4149584. This SNP, rs1800693, is more common but increases risk less; the odds ratio is reported as 1.2 (CI: 1.10-1.31, p=1.6x10(-11)).10.1038/ng.401

GWAS snp
PMID [PMID 19525953]
Trait Multiple sclerosis
Title Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Risk Allele C
P-val 2E-11
Odds Ratio 1.20 [1.10-1.31]
? (A;A) (A;G) (G;G)