From SNPedia
rs3849942 is one of 2 SNPs from the ch 9p21.2 region associated in a large GWAS study with ALS risk, the other SNP being rs2814707.
The odds ratio for the minor rs3849942(A) allele was 1.15 (p=1.01x10e-8).[PMID 19734901]
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| PharmGKB | PA162928830 |
| Name | |
| Annotation | This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.000005; OR: 5.0 (1.7, 15.8)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:18615156 |
| Drugs | adalimumab, etanercept, infliximab |
| Diseases | Arthritis, Rheumatoid |
| Curation Level | Curated |
