From SNPedia
rs2814707 is one of 2 SNPs from the ch 9p21.2 region associated in a large GWAS study with
ALS risk, the other SNP being
rs3849942.
The odds ratio for the minor rs2814707(A) allele was 1.16 (p=7.45x10e-9).[PMID 19734901]
spittoon rs2814707(T) 1.16x odds of ALS
rs12608932(C) 1.2x odds of ALS
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| PharmGKB | PA162928829 |
| Name | |
| Annotation | This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.000002; OR: 5.2 (1.8, 16.7)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy. |
| Gene | MOBKL2B |
| Featue | |
| Evidence | PubMed ID:18615156 |
| Drugs | adalimumab, etanercept, infliximab |
| Diseases | Arthritis, Rheumatoid |
| Curation Level | Curated |
