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rs3814637

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
Make rs3814637(C;T)
Make rs3814637(T;T)
ReferenceGRCh38 38.1/142
Chromosome10
Position94761288
GeneCYP2C19
is asnp
is mentioned by
dbSNPrs3814637
dbSNP (classic)rs3814637
ClinGenrs3814637
ebirs3814637
HLIrs3814637
Exacrs3814637
Gnomadrs3814637
Varsomers3814637
LitVarrs3814637
Maprs3814637
PheGenIrs3814637
Biobankrs3814637
1000 genomesrs3814637
hgdprs3814637
ensemblrs3814637
geneviewrs3814637
scholarrs3814637
googlers3814637
pharmgkbrs3814637
gwascentralrs3814637
openSNPrs3814637
23andMers3814637
SNPshotrs3814637
SNPdbers3814637
MSV3drs3814637
GWAS Ctlgrs3814637
GMAF0.07897
Max Magnitude0

rs3814637 represents an intronic variant in the CYP2C19 gene. Although found within several CYP2C19 star alleles (CYP2C19*1.004, CYP2C19*1.005, and CYP2C19*15.001) that have normal function, the minor (T) allele of rs3814637 is associated with significantly lower maintenance doses of warfarin among UK BioBank participants.10.1101/2020.08.09.243311

? (C;C) (C;T) (T;T) 28


[PMID 21692828OA-icon.png] The Population Pharmacokinetics of R and S-Warfarin: Effect of Genetic and Clinical Factors

[PMID 17048007OA-icon.png] Association of warfarin dose with genes involved in its action and metabolism.

[PMID 18574025OA-icon.png] The largest prospective warfarin-treated cohort supports genetic forecasting.


[PMID 23941071OA-icon.png] Association of genetic polymorphisms with warfarin dose requirements in Chinese patients