From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
common
|
| (C;T)
|
|
1.20x risk for breast cancer
|
| (T;T)
|
|
1.64x risk for breast cancer
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
This SNP is basically a proxy for SNP rs1219648, which represents the SNP in the FGFR2 gene with the strongest association with breast cancer. [PMID 17529973]
[PMID 18845558] Based on a study of 1,049 Chinese breast cancer patients, carriers of risk alleles at three SNPs (rs2981582, rs1219648 and rs2420946) were at 1.36x increased risk for breast cancer (CI: 1.13-1.62, p = 0.001).
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
