Rs290487

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ReferenceGRCh37 37.1/131
Chromosome10
Position114909731
GeneTCF7L2
is asnp
is mentioned by
dbSNPrs290487
PheGenIrs290487
nextbiors290487
hapmaprs290487
1000 genomesrs290487
hgdprs290487
ensemblrs290487
gopubmedrs290487
geneviewrs290487
scholarrs290487
googlers290487
pharmgkbrs290487
gwascentralrs290487
openSNPrs290487
23andMers290487
23andMe allrs290487
SNP Nexus

SNPshotrs290487
SNPdbers290487
MSV3drs290487
GMAF0.2746
Max Magnitude
? (C;C) (C;T) (T;T) 28

[PMID 19509102] Genetic Variants of TCF7L2 are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults

OMIM602228
DescTRANSCRIPTION FACTOR 7-LIKE 2; TCF7L2
Variant
Relatedalso


[PMID 19718565] Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2 are not associated with polycystic ovary syndrome in Chinese women


[PMID 20054294] KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) Polymorphisms Affect Therapeutic Efficacy of Repaglinide in Chinese Patients With Type 2 Diabetes





[PMID 22296403] Common variants of transcription factor 7-like 2 (TCF7L2) are associated with reduced insulin secretion in women with polycystic ovary syndrome

[PMID 17579206] Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population.

[PMID 18097733] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.

[PMID 18493736] Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population.

[PMID 19482368] Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.

[PMID 20161779OA-icon.png] Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.


[PMID 23041303] Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population


GET Evidence
rs290487
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.257812
summary



[PMID 23536853OA-icon.png] Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population


[PMID 23311683OA-icon.png] Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population


[PMID 23558246] Impacts of TCF7L2 gene polymorphisms on the susceptibility of hepatogenous diabetes and hepatocellular carcinoma in cirrhotic patients


[PMID 23188737] TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects


[PMID 23010200] Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population: a meta-analysis.


[PMID 24002895] Rs290487 of TCF7L2 gene is not associated with type 2 diabetes in Chinese Han population: a case control study and meta-analysis