Rs2333227

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Orientationplus
is asnp
is mentioned by
dbSNPrs2333227
PheGenIrs2333227
nextbiors2333227
hapmaprs2333227
1000 genomesrs2333227
hgdprs2333227
ensemblrs2333227
gopubmedrs2333227
geneviewrs2333227
scholarrs2333227
googlers2333227
pharmgkbrs2333227
gwascentralrs2333227
openSNPrs2333227
23andMers2333227
23andMe allrs2333227
SNP Nexus

SNPshotrs2333227
SNPdbers2333227
MSV3drs2333227
GeneMPO
Chromosome17
Orientationplus
GMAF0.2273
Position56358762
ReferenceGRCh37 37.1/131
Max Magnitude
Geno Mag Summary
(C;C)
(C;T) 0.8x decreased risk for lung cancer among smokers; increased gastric cancer risk
(T;T) 0.7x decreased risk for lung cancer among smokers; increased gastric cancer risk

rs2333227 is a SNP in the promoter region of the myeloperoxidase MPO gene; it is also known as the -463 variant. It has been implicated in Alzheimer's disease, lung cancer, gastric cancer, and lupus nephritis in SLE patients.

In connection with Alzheimer's disease (AD):

  • A study of 127 Finnish patients concluded that the rs2333227(T) allele increased the risk of Alzheimer's disease by 3.8 fold. This was derived by noting that a man with an ApoE allele has an AD odds ratio of 3.0 if they don't also have an rs2333227(T) allele, and an odds ratio of 11.4 if they do.[PMID 11087769]
  • A study of 148 Italian sporadic AD patients yielded an odds ratio for the rs2333227(C;C) genotype (as oriented in dbSNP orientation) of 1.78 (CI: 1.13-2.80). The presence of rs669(G;G), in addition to rs2333227(C;C), appears to synergistically increase the risk of AD to an odds ratio of 25.5 (CI: 4.65-139.75), regardless of ApoE status.[PMID 15023809]

In connection with lung cancer:

  • A pooled analysis of data from 10 studies (3688 cases) found an odds ratio for lung cancer of 0.88 (CI: 0.80-0.97) for rs2333227(C;T) heterozygotes, and 0.71 (CI: 0.57-0.88) for (T;T) homozygotes. This protective effect applied to both men and women, and appeared to apply to "ever" smokers but not "never" smokers.[PMID 17304047]

In connection with lupus nephritis:

  • While there was no association with lupus (SLE) per se in this study of 200+ African-American patients, the risk of developing lupus nephritis among SLE patients was significantly higher among rs2333227(C;T) heterozygotes compared with (C;C) homozygotes (odds ratio 2.11, CI: 1.12-3.97), and it was even higher for (T;T) homozygotes versus (C;C) (odds ratio 3.52, CI: 1.41-8.77).[PMID 17896805OA-icon.png]

In connection with gastric cancer:

  • rs2333227(T) carriers are at increased risk for gastric cancer, based on a study of 157 Taiwanese patients. If they are also H. pylori-infected, they have a 7.9x increased risk of gastric cancer, either intestinal or diffuse types.[PMID 18505072]


[PMID 20663217OA-icon.png] Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China


[PMID 21795425OA-icon.png] Genetic Variation in Myeloperoxidase Modifies the Association of Serum {alpha}-Tocopherol with Aggressive Prostate Cancer among Current Smokers


[PMID 22427832OA-icon.png] Menopausal Status Modifies Breast Cancer Risk Associated with the Myeloperoxidase (MPO) G463A Polymorphism in Caucasian Women: A Meta-Analysis


[PMID 15576619OA-icon.png] Hematotoxicity in workers exposed to low levels of benzene.


[PMID 16385446OA-icon.png] A testing framework for identifying susceptibility genes in the presence of epistasis.


[PMID 17885617] Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.


[PMID 18214807] Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery.


[PMID 18296681OA-icon.png] Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort.


[PMID 18340529OA-icon.png] A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.


[PMID 18632753OA-icon.png] Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.


[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 19438866OA-icon.png] Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.


[PMID 19479063OA-icon.png] Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.


[PMID 20445800OA-icon.png] Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy.


[PMID 21950958] Plasma myeloperoxidase level and peripheral arterial disease.


[PMID 23167629] Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review


[PMID 24567965] Haptoglobin and myeloperoxidase (- G463A) gene polymorphisms in Brazilian sickle cell patients with and without secondary iron overload


[PMID 23175176] Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.