Rs2241766
| is a | snp |
| is | mentioned by |
| dbSNP | rs2241766 |
| nextbio | rs2241766 |
| hapmap | rs2241766 |
| 1000 genomes | rs2241766 |
| hgdp | rs2241766 |
| ensembl | rs2241766 |
| gopubmed | rs2241766 |
| scholar | rs2241766 |
| rs2241766 | |
| pharmgkb | rs2241766 |
| gwascentral | rs2241766 |
| openSNP | rs2241766 |
| 23andMe | rs2241766 |
| 23andMe all | rs2241766 |
| SNP Nexus | |
| SNPshot | rs2241766 |
| SNPdbe | rs2241766 |
| MSV3d | rs2241766 |
| Gene | ADIPOQ |
| Chromosome | 3 |
| Orientation | plus |
| Position | 186570892 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 0 |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | normal |
| (G;T) | ||
| (T;T) | 0 | normal |
Adiponectin signaling status was assigned as follows:
rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler
Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.
Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism.
In other words, you are a low adiponectin signaler, and thus possibly at 6-fold higher risk of breast cancer, if you have one of these combinations of alleles:
You are an intermediate adiponectin signaler, and thus possibly at 4-fold higher risk of breast cancer, if you have one of these combinations of alleles:
- rs1501299 GG and also rs2241766 GG
- rs1501299 GT and also rs2241766 GT
- rs1501299 TT and also rs2241766 TT
You are a high adiponectin signaler if you have one of these combinations of alleles:
| Neighbor | rs1501299 |
| Distance | 231 |
[PMID 19573164] Association Study and Mutation Analysis of Adiponectin Shows Association of Variants in APM1 with Complex Obesity in Women
| OMIM | 612556 |
| Desc | ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1; ADIPQTL1 |
| Variant | |
| Related | also |
[PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis
[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese
[PMID 20414354] Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus
[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population
[PMID 20664545] Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases
[PMID 21397927] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk
[PMID 21516303] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
[PMID 21619462] The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer
[PMID 21630088] Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults
[PMID 21637951] A common variant in the adiponectin gene and polycystic ovary syndrome risk
[PMID 21726267] A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population
[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects