Rs2241766

A study of 733 breast cancer cases for 10 SNPs concluded that the rs2241766(G;T) genotype, in combination with certain genotypes at rs1501299, was at reduced risk (odds ratio 0.61, CI: 0.46-0.80). After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001).[PMID 18451143]

Adiponectin signaling status was assigned as follows:

rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler

Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.

Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism.

In other words, you are a low adiponectin signaler, and thus possibly at 6-fold higher risk of breast cancer, if you have one of these combinations of alleles:

• rs1501299 GG and also rs2241766 either GT or TT
• rs1501299 GT and also rs2241766 TT

You are an intermediate adiponectin signaler, and thus possibly at 4-fold higher risk of breast cancer, if you have one of these combinations of alleles:

• rs1501299 GG and also rs2241766 GG
• rs1501299 GT and also rs2241766 GT
• rs1501299 TT and also rs2241766 TT

You are a high adiponectin signaler if you have one of these combinations of alleles:

• rs1501299 GT and also rs2241766 GG
• rs1501299 TT and also rs2241766 either GG or GT

[PMID 19573164] Association Study and Mutation Analysis of Adiponectin Shows Association of Variants in APM1 with Complex Obesity in Women

[PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis

[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese

[PMID 20414354] Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus

[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

[PMID 20664545] Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

[PMID 21397927] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk

[PMID 21516303] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes

[PMID 21619462] The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer

[PMID 21630088] Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults

[PMID 21637951] A common variant in the adiponectin gene and polycystic ovary syndrome risk

[PMID 21726267] A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population

[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects