From SNPedia
A study of 733 breast cancer cases for 10 SNPs concluded that the rs1501299(C;C) genotype (in dbSNP orientation) was at increased risk (odds ratio 1.80, CI: 1.14 - 2.85).[PMID 18451143]
After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001).[PMID 18451143]
Adiponectin signaling status was assigned as follows:
rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler
Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.
| ? | (A;A) (A;C) (C;C) |
|---|
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[PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis
[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese
