Rs1501299

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Orientationminus
is asnp
is mentioned by
dbSNPrs1501299
PheGenIrs1501299
nextbiors1501299
hapmaprs1501299
1000 genomesrs1501299
hgdprs1501299
ensemblrs1501299
gopubmedrs1501299
geneviewrs1501299
scholarrs1501299
googlers1501299
pharmgkbrs1501299
gwascentralrs1501299
openSNPrs1501299
23andMers1501299
23andMe allrs1501299
SNP Nexus

SNPshotrs1501299
SNPdbers1501299
MSV3drs1501299
GeneADIPOQ, ADIPOQ-AS1
Chromosome3
Orientationminus
GMAF0.32
Position186571123
ReferenceGRCh37.p5 37.3/137
Max Magnitude0
Geno Mag Summary
(A;A) 0 normal
(A;C) normal
(C;C) 1.8x higher breast cancer risk
? (A;A) (A;C) (C;C) 28

A study of 733 breast cancer cases for 10 SNPs concluded that the rs1501299(C;C) genotype (in dbSNP orientation) was at increased risk (odds ratio 1.80, CI: 1.14 - 2.85). After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001). [PMID 18451143OA-icon.png]

Adiponectin signaling status was assigned as follows:

rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler

Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.

Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism as well as glucose regulation.

In other words, you are a low adiponectin signaler, and thus possibly at 6-fold higher risk of breast cancer, if you have one of these combinations of alleles:

You are an intermediate adiponectin signaler, and thus possibly at 4-fold higher risk of breast cancer, if you have one of these combinations of alleles:

You are a high adiponectin signaler if you have one of these combinations of alleles:

This is one of the SNPs reported by NutraHacker.

Neighborrs2241766
Distance231


[PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis

[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese


[PMID 19761474OA-icon.png] Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study

[PMID 20414354OA-icon.png] Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus

[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

[PMID 20664545] Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

[PMID 20697428OA-icon.png] Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans

OMIM612556
Desc
Variant
Relatedalso
[PMID 21397927OA-icon.png] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk


[PMID 21516303OA-icon.png] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes


[PMID 21630088] Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults


[PMID 21637951] A common variant in the adiponectin gene and polycystic ovary syndrome risk


[PMID 21694446OA-icon.png] Associations of single nucleotide polymorphisms in the adiponectin gene with adiponectin levels and cardio-metabolic risk factors in patients with cancer


[PMID 21726267] A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population


[PMID 21562092OA-icon.png] Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome


[PMID 22040602] Recessive protective effect of ADIPOQ rs1501299 on cardiovascular diseases with type 2 diabetes: A meta-analysis


[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects


[PMID 22714914] Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese


[PMID 22748670] Association of the adiponectin gene rs1501299 G>T variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population


[PMID 15616038] Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene.


[PMID 16990411] Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.


[PMID 17712123] Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.


[PMID 18398047] Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers.


[PMID 18523726OA-icon.png] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 18716158OA-icon.png] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.


[PMID 18776141OA-icon.png] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.


[PMID 18827209OA-icon.png] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.


[PMID 19037660OA-icon.png] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.


[PMID 19056609OA-icon.png] Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy.


[PMID 19238139OA-icon.png] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.


[PMID 19543786] ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity.


[PMID 19755407OA-icon.png] Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women.


[PMID 19912668OA-icon.png] Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study.


[PMID 20201642] Associations of polymorphisms in adiponectin and leptin genes with men's longevity.


[PMID 20230294] Analysis of adiponectin gene polymorphisms in dilated cardiomyopathy in a Han Chinese population.


[PMID 20421984OA-icon.png] FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals.


[PMID 20528971] Low plasma adiponectin concentration is associated with myocardial infarction in young individuals.


[PMID 20835900OA-icon.png] Genetics of diabetes complications.


[PMID 20848215] Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.


[PMID 21054480] Genetic effects of adiponectin on blood lipids and blood pressure.


[PMID 21073447] Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients.


[PMID 21219602OA-icon.png] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.


[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.


[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.


[PMID 21820140] The relationship between adiponectin, an adiponectin gene polymorphism, and high-density lipoprotein particle size: from the Mima study.


[PMID 22386722] Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.


[PMID 22391941] Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.


[PMID 22565227] Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.


[PMID 22583123OA-icon.png] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.


[PMID 23041095] Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction


[PMID 23151860] +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia


[PMID 23200411] ADIPOQ gene polymorphisms and cancer risk: A meta-analysis


[PMID 23370338] Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure


[PMID 23590551OA-icon.png] Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes


[PMID 23624817OA-icon.png] Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative


[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study


[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals


[PMID 23740135] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk


[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia


[PMID 23260797] Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes


[PMID 23819115OA-icon.png] Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study


[PMID 23922565OA-icon.png] Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease


[PMID 24055485] Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population


[PMID 24559720] Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome


[PMID 23065236] The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.


[PMID 23225349] Three adiponectin rs1501299G/T, rs822395A/C, and rs822396A/G polymorphisms and risk of cancer development: a meta-analysis.


[PMID 23552441] Association of adiponectin gene polymorphism with birth weight in Korean neonates.