Rs1864010
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1864010 |
| hapmap | rs1864010 |
| hgdp | rs1864010 |
| ensembl | rs1864010 |
| gopubmed | rs1864010 |
| scholar | rs1864010 |
| rs1864010 | |
| pharmgkb | rs1864010 |
| hgvbaseg2p | rs1864010 |
| medrefsnp | rs1864010 |
| 23andMe | rs1864010 |
| SNP Nexus |
| Gene | INSR |
| Chromosome | 19 |
| Orientation | minus |
| Position | 7245504 |
| Genotype | Effect |
|---|---|
| rs1864010(A;A) | reduced colorectal risk |
| rs1864010(A;G) | reduced colorectal risk |
| rs1864010(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1864010(A;A) | reduced colorectal risk | |
| Rs1864010(A;G) | reduced colorectal risk | |
| Rs1864010(G;G) | normal |
[PMID 17914103] The INSR A-603G promoter rs1864010 SNP, which is located within a known Sp1-binding site, was associated with the risk of colorectal cancer, with carriers of the G allele having a decreased risk (odds ratios 0.71, CI: 0.54-0.93). Carrying the variant allele of the IRS1 Gly972Arg rs1801278 SNP further decreased the risk among the INSR-603G allele carriers (OR 0.28, 95% CI 0.11-0.70).
| Neighbor | rs7508518 |
| Distance | 607 |
