Rs1801278

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is asnp
is mentioned by
dbSNPrs1801278
hapmaprs1801278
hgdprs1801278
ensemblrs1801278
gopubmedrs1801278
scholarrs1801278
googlers1801278
pharmgkbrs1801278
hgvbaseg2prs1801278
medrefsnprs1801278
23andMers1801278
SNP Nexus

GeneIRS1
Chromosome2
Orientationminus
Position227368787
GenotypeEffect
rs1801278(A;A)reduced colorectal risk when combined with INSR SNP
rs1801278(A;G)reduced colorectal risk when combined with INSR SNP
rs1801278(G;G)normal


Genotypes Magnitude Summary
Rs1801278(A;A) reduced colorectal risk when combined with INSR SNP
Rs1801278(A;G) reduced colorectal risk when combined with INSR SNP
Rs1801278(G;G) 00 normal
[PMID 17914103] The INSR A-603G promoter rs1864010 SNP, which is located within a known Sp1-binding site, was associated with the risk of colorectal cancer, with carriers of the G allele having a decreased risk (odds ratios (OR) 0.71, 95% confidence interval (CI) 0.54-0.93). Carrying the variant allele of the IRS1 Gly972Arg rs1801278 SNP further decreased the risk among the INSR-603G allele carriers (OR 0.28, 95% CI 0.11-0.70)

[PMID 19124510] multiple myeloma

  • rs1801278 [C/T versus C/C genotypes; OR, 4.3; 95% confidence interval (CI), 1.5-12.1]
  • rs6684439 (T/T versus C/C; OR, 2.9; 95% CI, 1.2-7.0)
  • rs7529229 (C/C versus T/T; OR, 2.5; 95% CI, 1.1-6.0)
  • rs8192284 (C/C versus A/A; OR, 2.5, 95% CI, 1.1-6.0)
? (A;G)
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